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Association of silent lacunar infarct with brain atrophy and cognitive impairment.

Publication ,  Journal Article
Thong, JYJ; Hilal, S; Wang, Y; Soon, HW; Dong, Y; Collinson, SL; Anh, TT; Ikram, MK; Wong, TY; Venketasubramanian, N; Chen, C; Qiu, A
Published in: J Neurol Neurosurg Psychiatry
November 2013

OBJECTIVE: Silent lacunar infarct (SLI) is associated with cognitive decline and linked to an increased risk of stroke and dementia. We examined the association of SLI with MRI measures of cortical thickness, subcortical and lateral ventricular shapes and cognition in 285 ethnic Chinese elderly. METHODS: SLI, cortical thickness, shapes of subcortical and ventricular structures were quantified using MRI. The cognitive performance was assessed using comprehensive neuropsychological tests. Linear regression was used to examine associations among SLI, brain measures and cognition. RESULTS: SLI was associated with atrophy in multiple subcortical structures, ventricular enlargement and widespread cortical thinning. Both SLI and atrophy were independently related to poorer performance in attention, memory and language domains. Only SLI was associated with visuomotor speed and executive function, while atrophy mediated the association between SLI and visuoconstruction. CONCLUSIONS: Our findings support a vascular contribution to neurodegeneration and cognitive impairment.

Duke Scholars

Published In

J Neurol Neurosurg Psychiatry

DOI

EISSN

1468-330X

Publication Date

November 2013

Volume

84

Issue

11

Start / End Page

1219 / 1225

Location

England

Related Subject Headings

  • Stroke, Lacunar
  • Singapore
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Mental Status Schedule
  • Male
  • Magnetic Resonance Imaging
  • Lateral Ventricles
  • Internal Capsule
  • Imaging, Three-Dimensional
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Thong, J. Y. J., Hilal, S., Wang, Y., Soon, H. W., Dong, Y., Collinson, S. L., … Qiu, A. (2013). Association of silent lacunar infarct with brain atrophy and cognitive impairment. J Neurol Neurosurg Psychiatry, 84(11), 1219–1225. https://doi.org/10.1136/jnnp-2013-305310
Thong, Jamie Yu Jin, Saima Hilal, Yanbo Wang, Hock Wei Soon, Yanhong Dong, Simon Lowes Collinson, Tuan Ta Anh, et al. “Association of silent lacunar infarct with brain atrophy and cognitive impairment.J Neurol Neurosurg Psychiatry 84, no. 11 (November 2013): 1219–25. https://doi.org/10.1136/jnnp-2013-305310.
Thong JYJ, Hilal S, Wang Y, Soon HW, Dong Y, Collinson SL, et al. Association of silent lacunar infarct with brain atrophy and cognitive impairment. J Neurol Neurosurg Psychiatry. 2013 Nov;84(11):1219–25.
Thong, Jamie Yu Jin, et al. “Association of silent lacunar infarct with brain atrophy and cognitive impairment.J Neurol Neurosurg Psychiatry, vol. 84, no. 11, Nov. 2013, pp. 1219–25. Pubmed, doi:10.1136/jnnp-2013-305310.
Thong JYJ, Hilal S, Wang Y, Soon HW, Dong Y, Collinson SL, Anh TT, Ikram MK, Wong TY, Venketasubramanian N, Chen C, Qiu A. Association of silent lacunar infarct with brain atrophy and cognitive impairment. J Neurol Neurosurg Psychiatry. 2013 Nov;84(11):1219–1225.

Published In

J Neurol Neurosurg Psychiatry

DOI

EISSN

1468-330X

Publication Date

November 2013

Volume

84

Issue

11

Start / End Page

1219 / 1225

Location

England

Related Subject Headings

  • Stroke, Lacunar
  • Singapore
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Mental Status Schedule
  • Male
  • Magnetic Resonance Imaging
  • Lateral Ventricles
  • Internal Capsule
  • Imaging, Three-Dimensional