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Metabolic syndrome and risk of age-related cataract over time: an analysis of interval-censored data using a random-effects model.

Publication ,  Journal Article
Ghaem Maralani, H; Tai, BC; Wong, TY; Tai, ES; Li, J; Wang, JJ; Mitchell, P
Published in: Invest Ophthalmol Vis Sci
January 21, 2013

PURPOSE: To investigate whether the effect of metabolic syndrome (MetS) and its components on the incidence of different cataract subtypes (cortical, nuclear, and posterior subcapsular cataract [PSC]) change with time. METHODS: A prospective cohort of persons 49 years of age and older were followed over 10 years in the Blue Mountains Eye Study, west of Sydney, Australia. MetS components as defined by the International Diabetes Federation criteria were measured at baseline (1992-1994), after 5 years (1997-1999), and after 10 years (2002-2004). The incidence of different cataract subtypes was obtained from standard photographic grading at these intervals (n = 1997). Using a random-effects complementary log-log regression model with time to cataract development in discrete time interval, we estimated the effect of MetS and its components on the incidence of different cataract subtypes at different time intervals. RESULTS: After accounting for changes in MetS components over time and controlling for possible confounders, MetS was found to be associated with an increased 5-year incidence of cortical cataract (hazard ratio [HR] 1.48; 95% confidence interval [CI], 1.05-2.09) and PSC cataract (HR 1.75; 95% CI, 1.01-3.04). Among the five MetS components, high glucose and obesity predicted an increased 5-year incidence of cortical cataract. In addition, low high-density lipoprotein and high glucose were associated with an increased 10-year incidence of cortical and PSC cataracts, respectively. CONCLUSIONS: Changes in MetS predicted the 5-year incidence of cortical and PSC cataracts. Different MetS components predicted the incidence of cortical and PSC cataracts at varying time intervals.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

January 21, 2013

Volume

54

Issue

1

Start / End Page

641 / 646

Location

United States

Related Subject Headings

  • Triglycerides
  • Time Factors
  • Risk Factors
  • Prospective Studies
  • Ophthalmology & Optometry
  • Obesity
  • New South Wales
  • Middle Aged
  • Metabolic Syndrome
  • Male
 

Citation

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ICMJE
MLA
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Ghaem Maralani, H., Tai, B. C., Wong, T. Y., Tai, E. S., Li, J., Wang, J. J., & Mitchell, P. (2013). Metabolic syndrome and risk of age-related cataract over time: an analysis of interval-censored data using a random-effects model. Invest Ophthalmol Vis Sci, 54(1), 641–646. https://doi.org/10.1167/iovs.12-10980
Ghaem Maralani, Haleh, Bee Choo Tai, Tien Y. Wong, E Shyong Tai, Jialiang Li, Jie Jin Wang, and Paul Mitchell. “Metabolic syndrome and risk of age-related cataract over time: an analysis of interval-censored data using a random-effects model.Invest Ophthalmol Vis Sci 54, no. 1 (January 21, 2013): 641–46. https://doi.org/10.1167/iovs.12-10980.
Ghaem Maralani H, Tai BC, Wong TY, Tai ES, Li J, Wang JJ, et al. Metabolic syndrome and risk of age-related cataract over time: an analysis of interval-censored data using a random-effects model. Invest Ophthalmol Vis Sci. 2013 Jan 21;54(1):641–6.
Ghaem Maralani, Haleh, et al. “Metabolic syndrome and risk of age-related cataract over time: an analysis of interval-censored data using a random-effects model.Invest Ophthalmol Vis Sci, vol. 54, no. 1, Jan. 2013, pp. 641–46. Pubmed, doi:10.1167/iovs.12-10980.
Ghaem Maralani H, Tai BC, Wong TY, Tai ES, Li J, Wang JJ, Mitchell P. Metabolic syndrome and risk of age-related cataract over time: an analysis of interval-censored data using a random-effects model. Invest Ophthalmol Vis Sci. 2013 Jan 21;54(1):641–646.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

January 21, 2013

Volume

54

Issue

1

Start / End Page

641 / 646

Location

United States

Related Subject Headings

  • Triglycerides
  • Time Factors
  • Risk Factors
  • Prospective Studies
  • Ophthalmology & Optometry
  • Obesity
  • New South Wales
  • Middle Aged
  • Metabolic Syndrome
  • Male