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Retinal vascular calibre as a predictor of incidence and progression of diabetic retinopathy.

Publication ,  Journal Article
Ding, J; Ikram, MK; Cheung, CY; Wong, TY
Published in: Clin Exp Optom
May 2012

Recent advances in retinal photographic imaging techniques have allowed objective and precise measurement of subtle vascular characteristics in the retina, including the retinal vessel calibre (diameter). Data from population-based and clinic-based studies show that changes in retinal calibre are associated with systemic vascular risk factors and might reflect early microcirculatory alterations in people with diabetes prior to the onset of clinically significant complications, such as diabetic retinopathy. Prospective studies suggest that in people with type 1 diabetes, wider retinal venules are associated with progression of mild to more severe levels of retinopathy, including proliferative retinopathy. Thus, studying retinal vascular calibre changes might offer the potential to improve our understanding of the early pathophysiological pathways of diabetic retinopathy, potentially allowing the development of novel therapies. Future research is still needed to assess the ability of retinal vessel calibre measures to provide clinically useful prognostic information that might add to risk prediction of diabetic retinopathy over and above the contribution from traditional risk factors, including glycaemic levels and the duration of diabetes.

Duke Scholars

Published In

Clin Exp Optom

DOI

EISSN

1444-0938

Publication Date

May 2012

Volume

95

Issue

3

Start / End Page

290 / 296

Location

United States

Related Subject Headings

  • Risk Factors
  • Retinal Vessels
  • Ophthalmology & Optometry
  • Longitudinal Studies
  • Incidence
  • Humans
  • Disease Progression
  • Diabetic Retinopathy
  • Diabetes Mellitus, Type 2
  • Diabetes Mellitus, Type 1
 

Citation

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ICMJE
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Ding, J., Ikram, M. K., Cheung, C. Y., & Wong, T. Y. (2012). Retinal vascular calibre as a predictor of incidence and progression of diabetic retinopathy. Clin Exp Optom, 95(3), 290–296. https://doi.org/10.1111/j.1444-0938.2012.00725.x
Ding, Jie, M Kamran Ikram, Carol Y. Cheung, and Tien Yin Wong. “Retinal vascular calibre as a predictor of incidence and progression of diabetic retinopathy.Clin Exp Optom 95, no. 3 (May 2012): 290–96. https://doi.org/10.1111/j.1444-0938.2012.00725.x.
Ding J, Ikram MK, Cheung CY, Wong TY. Retinal vascular calibre as a predictor of incidence and progression of diabetic retinopathy. Clin Exp Optom. 2012 May;95(3):290–6.
Ding, Jie, et al. “Retinal vascular calibre as a predictor of incidence and progression of diabetic retinopathy.Clin Exp Optom, vol. 95, no. 3, May 2012, pp. 290–96. Pubmed, doi:10.1111/j.1444-0938.2012.00725.x.
Ding J, Ikram MK, Cheung CY, Wong TY. Retinal vascular calibre as a predictor of incidence and progression of diabetic retinopathy. Clin Exp Optom. 2012 May;95(3):290–296.
Journal cover image

Published In

Clin Exp Optom

DOI

EISSN

1444-0938

Publication Date

May 2012

Volume

95

Issue

3

Start / End Page

290 / 296

Location

United States

Related Subject Headings

  • Risk Factors
  • Retinal Vessels
  • Ophthalmology & Optometry
  • Longitudinal Studies
  • Incidence
  • Humans
  • Disease Progression
  • Diabetic Retinopathy
  • Diabetes Mellitus, Type 2
  • Diabetes Mellitus, Type 1