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Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis.

Publication ,  Journal Article
Fernandez, AB; Wong, TY; Klein, R; Collins, D; Burke, G; Cotch, MF; Klein, B; Sadeghi, MM; Chen, J
Published in: Ophthalmology
April 2012

OBJECTIVE: To determine whether age-related macular degeneration (AMD) is a risk indicator for coronary heart disease (CHD) and cardiovascular disease (CVD) events independent of other known risk factors in a multi-ethnic cohort. DESIGN: Population-based prospective cohort study. PARTICIPANTS: A diverse population sample of 6233 men and women aged 45 to 84 years without known CVD from the Multi-Ethnic Study of Atherosclerosis (MESA). METHODS: Participants in the MESA had retinal photographs taken between 2002 and 2003. Photographs were evaluated for AMD. Incident CHD and CVD events were ascertained during clinical follow-up visits for up to 8 years after the retinal images were taken. MAIN OUTCOME MEASURES: Incident CHD and CVD events. RESULTS: Of the 6814 persons at risk of CHD, there were 893 participants with early AMD (13.1%) and 27 patients (0.5%) at baseline. Over a mean follow-up period of 5.4 years, there was no statistically significant difference in incident CHD or CVD between the AMD and non-AMD groups (5.0% vs. 3.9%, P = 0.13 for CHD and 6.6% vs. 5.5%, P = 0.19 for CVD). In Cox regression models adjusting for CVD risk factors, there was no significant relationship between presence of any AMD and any CHD/CVD events (hazard ratio 0.99; 95% confidence interval, 0.74-1.33; P = 0.97). No significant association was found between subgroups of early AMD or late AMD and incident CHD/CVD events. CONCLUSIONS: In persons without a history of CVD, AMD was not associated with an increased risk of CHD or CVD.

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Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

April 2012

Volume

119

Issue

4

Start / End Page

765 / 770

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Degeneration
  • Incidence
  • Humans
  • Female
 

Citation

APA
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ICMJE
MLA
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Fernandez, A. B., Wong, T. Y., Klein, R., Collins, D., Burke, G., Cotch, M. F., … Chen, J. (2012). Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Ophthalmology, 119(4), 765–770. https://doi.org/10.1016/j.ophtha.2011.09.044
Fernandez, Antonio B., Tien Y. Wong, Ronald Klein, Dorothea Collins, Gregory Burke, Mary Frances Cotch, Barbara Klein, Mehran M. Sadeghi, and Jersey Chen. “Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis.Ophthalmology 119, no. 4 (April 2012): 765–70. https://doi.org/10.1016/j.ophtha.2011.09.044.
Fernandez AB, Wong TY, Klein R, Collins D, Burke G, Cotch MF, et al. Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Ophthalmology. 2012 Apr;119(4):765–70.
Fernandez, Antonio B., et al. “Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis.Ophthalmology, vol. 119, no. 4, Apr. 2012, pp. 765–70. Pubmed, doi:10.1016/j.ophtha.2011.09.044.
Fernandez AB, Wong TY, Klein R, Collins D, Burke G, Cotch MF, Klein B, Sadeghi MM, Chen J. Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Ophthalmology. 2012 Apr;119(4):765–770.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

April 2012

Volume

119

Issue

4

Start / End Page

765 / 770

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Degeneration
  • Incidence
  • Humans
  • Female