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Retinal vascular calibre and the risk of coronary heart disease-related death.

Publication ,  Journal Article
Wang, JJ; Liew, G; Wong, TY; Smith, W; Klein, R; Leeder, SR; Mitchell, P
Published in: Heart
November 2006

OBJECTIVE: To examine whether retinal vascular calibre independently predicts risk of coronary heart disease (CHD) -related death. METHODS: In a population-based cohort study of 3654 Australians aged > or = 49 years, retinal arteriolar and venular calibres were measured from baseline retinal photographs and the arteriole to venule ratio (AVR) was calculated. CHD-related death was confirmed from the Australian National Death Index. RESULTS: Over nine years, 78 women (4.1%) and 114 men (7.8%) had incident CHD-related deaths. In people aged 49-75 years, wider venules were associated with CHD death, with relative risk (RR) 1.8 (95% confidence interval (CI) 1.1 to 2.7) and RR 2.0 (95% CI 1.1 to 3.6) per standard deviation (SD) increase in venular calibre for men and women, respectively, after adjustment for traditional risk factors. Additionally, in women aged 49-75 years, smaller AVR and narrower arterioles were associated with CHD death (RR 1.5, 95% CI 1.1 to 2.2, and RR 1.9, 95% CI 1.0 to 3.5 per SD decrease in AVR and arteriolar calibre, respectively, after adjustment). These associations were not observed in people aged > 75 years. CONCLUSIONS: These findings suggest that microvascular disease processes may have a role in CHD development in middle-aged people, particularly in women. Retinal photography may be useful in cardiovascular risk prediction.

Duke Scholars

Published In

Heart

DOI

EISSN

1468-201X

Publication Date

November 2006

Volume

92

Issue

11

Start / End Page

1583 / 1587

Location

England

Related Subject Headings

  • Risk Factors
  • Retinal Vessels
  • Regression Analysis
  • Middle Aged
  • Male
  • Hypertension
  • Humans
  • Fluorescein Angiography
  • Female
  • Diabetic Angiopathies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, J. J., Liew, G., Wong, T. Y., Smith, W., Klein, R., Leeder, S. R., & Mitchell, P. (2006). Retinal vascular calibre and the risk of coronary heart disease-related death. Heart, 92(11), 1583–1587. https://doi.org/10.1136/hrt.2006.090522
Wang, J. J., G. Liew, T. Y. Wong, W. Smith, R. Klein, S. R. Leeder, and P. Mitchell. “Retinal vascular calibre and the risk of coronary heart disease-related death.Heart 92, no. 11 (November 2006): 1583–87. https://doi.org/10.1136/hrt.2006.090522.
Wang JJ, Liew G, Wong TY, Smith W, Klein R, Leeder SR, et al. Retinal vascular calibre and the risk of coronary heart disease-related death. Heart. 2006 Nov;92(11):1583–7.
Wang, J. J., et al. “Retinal vascular calibre and the risk of coronary heart disease-related death.Heart, vol. 92, no. 11, Nov. 2006, pp. 1583–87. Pubmed, doi:10.1136/hrt.2006.090522.
Wang JJ, Liew G, Wong TY, Smith W, Klein R, Leeder SR, Mitchell P. Retinal vascular calibre and the risk of coronary heart disease-related death. Heart. 2006 Nov;92(11):1583–1587.

Published In

Heart

DOI

EISSN

1468-201X

Publication Date

November 2006

Volume

92

Issue

11

Start / End Page

1583 / 1587

Location

England

Related Subject Headings

  • Risk Factors
  • Retinal Vessels
  • Regression Analysis
  • Middle Aged
  • Male
  • Hypertension
  • Humans
  • Fluorescein Angiography
  • Female
  • Diabetic Angiopathies