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Retinal vascular geometry predicts incident retinopathy in young people with type 1 diabetes: a prospective cohort study from adolescence.

Publication ,  Journal Article
Benitez-Aguirre, P; Craig, ME; Sasongko, MB; Jenkins, AJ; Wong, TY; Wang, JJ; Cheung, N; Donaghue, KC
Published in: Diabetes Care
July 2011

OBJECTIVE: To examine the association between retinal vascular geometry and subsequent development of incident retinopathy in young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: A prospective cohort study of 736 people with type 1 diabetes aged 12 to 20 years, retinopathy-free at baseline, attending an Australian tertiary care hospital. Retinopathy was determined from seven-field retinal photographs according to the modified Airlie House Classification. Retinal vascular geometry, including length/diameter ratio (LDR) and simple tortuosity (ST), was quantified in baseline retinal photographs. Generalized estimating equations were used to determine risk of retinopathy associated with baseline LDR and ST, adjusting for other factors. RESULTS: After a median 3.8 (interquartile range 2.4-6.1) years of follow-up, incident retinopathy developed in 287 of 736 (39%). In multivariate analysis, lower arteriolar LDR (odds ratio 1.8 [95% CI 1.2-2.6]; 1st vs. 4th quartile) and greater arteriolar ST (1.5 [1.0-2.2]; 4th vs. 1st quartile) predicted incident retinopathy after adjusting for diabetes duration, sex, A1C, blood pressure, total cholesterol, and BMI. In subgroup analysis by sex, LDR predicted incident retinopathy in male and female participants (2.1 [1.1-4.0] and 1.7 [1.1-2.7]; 1st vs. 4th quartiles, respectively) and greater arteriolar ST predicted incident retinopathy in male participants (2.4 [1.1-4.4]; 4th vs. 1st quartile) only. CONCLUSIONS: Lower arteriolar LDR and greater ST were independently associated with incident retinopathy in young people with type 1 diabetes. These vascular geometry measures may serve as risk markers for diabetic retinopathy and provide insights into the early structural changes in diabetic microvascular complications.

Duke Scholars

Published In

Diabetes Care

DOI

EISSN

1935-5548

Publication Date

July 2011

Volume

34

Issue

7

Start / End Page

1622 / 1627

Location

United States

Related Subject Headings

  • Young Adult
  • Retinal Vessels
  • Prospective Studies
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diabetic Retinopathy
  • Diabetes Mellitus, Type 1
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Benitez-Aguirre, P., Craig, M. E., Sasongko, M. B., Jenkins, A. J., Wong, T. Y., Wang, J. J., … Donaghue, K. C. (2011). Retinal vascular geometry predicts incident retinopathy in young people with type 1 diabetes: a prospective cohort study from adolescence. Diabetes Care, 34(7), 1622–1627. https://doi.org/10.2337/dc10-2419
Benitez-Aguirre, Paul, Maria E. Craig, Muhammad Bayu Sasongko, Alicia J. Jenkins, Tien Yin Wong, Jie Jin Wang, Ning Cheung, and Kim C. Donaghue. “Retinal vascular geometry predicts incident retinopathy in young people with type 1 diabetes: a prospective cohort study from adolescence.Diabetes Care 34, no. 7 (July 2011): 1622–27. https://doi.org/10.2337/dc10-2419.
Benitez-Aguirre P, Craig ME, Sasongko MB, Jenkins AJ, Wong TY, Wang JJ, et al. Retinal vascular geometry predicts incident retinopathy in young people with type 1 diabetes: a prospective cohort study from adolescence. Diabetes Care. 2011 Jul;34(7):1622–7.
Benitez-Aguirre, Paul, et al. “Retinal vascular geometry predicts incident retinopathy in young people with type 1 diabetes: a prospective cohort study from adolescence.Diabetes Care, vol. 34, no. 7, July 2011, pp. 1622–27. Pubmed, doi:10.2337/dc10-2419.
Benitez-Aguirre P, Craig ME, Sasongko MB, Jenkins AJ, Wong TY, Wang JJ, Cheung N, Donaghue KC. Retinal vascular geometry predicts incident retinopathy in young people with type 1 diabetes: a prospective cohort study from adolescence. Diabetes Care. 2011 Jul;34(7):1622–1627.

Published In

Diabetes Care

DOI

EISSN

1935-5548

Publication Date

July 2011

Volume

34

Issue

7

Start / End Page

1622 / 1627

Location

United States

Related Subject Headings

  • Young Adult
  • Retinal Vessels
  • Prospective Studies
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diabetic Retinopathy
  • Diabetes Mellitus, Type 1
  • Child