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Lipids and diabetic retinopathy.

Publication ,  Journal Article
Lim, LS; Wong, TY
Published in: Expert Opin Biol Ther
January 2012

INTRODUCTION: Diabetic retinopathy (DR) is a significant cause of visual impairment worldwide. The association between hyperlipidemia or dyslipidemia and DR has been investigated extensively, but a conclusive link remains elusive. This review summarizes the current knowledge regarding lipids and DR. AREAS COVERED: The clinical literature on the associations between the 'traditional' lipid markers and DR will be critically evaluated, along with some of the postulated biological mechanisms underlying the associations. The emergence of several novel 'non-traditional' lipid fractions as possible biomarkers for DR will also be discussed. The review will conclude by evaluating current lipid-lowering therapies in DR and also give an overview of other novel treatments targeting lipid pathways. EXPERT OPINION: Future studies need to address three important issues. First, the role of novel lipid biomarkers needs to be clarified in light of the persistent failure of epidemiological studies to demonstrate a clear association between traditional lipids and DR. Second, the pathways by which lipid-lowering therapies act in preventing the retinal complications of diabetes need to be elucidated. Last, identifying the patient profile that would benefit most from treatment is essential.

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Published In

Expert Opin Biol Ther

DOI

EISSN

1744-7682

Publication Date

January 2012

Volume

12

Issue

1

Start / End Page

93 / 105

Location

England

Related Subject Headings

  • Risk
  • Oxidative Stress
  • Models, Biological
  • Middle Aged
  • Macular Edema
  • Lipids
  • Immunology
  • Hyperlipidemias
  • Humans
  • Fundus Oculi
 

Citation

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Lim, L. S., & Wong, T. Y. (2012). Lipids and diabetic retinopathy. Expert Opin Biol Ther, 12(1), 93–105. https://doi.org/10.1517/14712598.2012.641531
Lim, Laurence S., and Tien Y. Wong. “Lipids and diabetic retinopathy.Expert Opin Biol Ther 12, no. 1 (January 2012): 93–105. https://doi.org/10.1517/14712598.2012.641531.
Lim LS, Wong TY. Lipids and diabetic retinopathy. Expert Opin Biol Ther. 2012 Jan;12(1):93–105.
Lim, Laurence S., and Tien Y. Wong. “Lipids and diabetic retinopathy.Expert Opin Biol Ther, vol. 12, no. 1, Jan. 2012, pp. 93–105. Pubmed, doi:10.1517/14712598.2012.641531.
Lim LS, Wong TY. Lipids and diabetic retinopathy. Expert Opin Biol Ther. 2012 Jan;12(1):93–105.

Published In

Expert Opin Biol Ther

DOI

EISSN

1744-7682

Publication Date

January 2012

Volume

12

Issue

1

Start / End Page

93 / 105

Location

England

Related Subject Headings

  • Risk
  • Oxidative Stress
  • Models, Biological
  • Middle Aged
  • Macular Edema
  • Lipids
  • Immunology
  • Hyperlipidemias
  • Humans
  • Fundus Oculi