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C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population.

Publication ,  Journal Article
Wen, J; Liang, Y; Wang, F; Sun, L; Guo, Y; Duan, X; Liu, X; Wong, TY; Lu, X; Wang, N
Published in: Clin Chim Acta
February 2010

BACKGROUND: We studied the association of C-reactive protein (CRP), gamma-glutamyltransferase (GGT) and type 2 diabetes in Chinese. METHOD: A population-based cross-sectional study. RESULTS: CRP and GGT levels were significantly higher in participants with diabetes than in those without (P<0.001). Higher CRP levels were positively associated with prevalent type 2 diabetes after adjustment for age, sex, smoking, alcohol consumption, physical activity, family history of diabetes, body mass index, waist circumference, waist/hip ratio, education, systolic blood pressure, triglycerides, high density lipoprotein cholesterol, use of antihypertensive drugs, aspirin and lipid-lowering agents, with multivariable odds ratios (OR) of 1.55 (95% confidence interval (CI), 1.05-2.27, P trend=0.005, comparing quartile 4 to quartile 1). However, after further adjustment for GGT, the association was completely attenuated (fourth quartile OR 1.23, 95% CI, 0.83-1.82, P trend=0.127). Moreover, the association of CRP and prevalent type 2 diabetes was stronger in subjects with GGT values above the median than in those with GGT values below the median. Increasing serum GGT quartiles were positively associated with prevalent type 2 diabetes after adjustment for potential confounding variables (P for trend <0.001). CONCLUSION: CRP may not be an independent risk factor for type 2 diabetes, at least in Chinese people.

Duke Scholars

Published In

Clin Chim Acta

DOI

EISSN

1873-3492

Publication Date

February 2010

Volume

411

Issue

3-4

Start / End Page

198 / 203

Location

Netherlands

Related Subject Headings

  • gamma-Glutamyltransferase
  • Risk Factors
  • Middle Aged
  • Humans
  • General Clinical Medicine
  • Female
  • Diabetes Mellitus, Type 2
  • China
  • C-Reactive Protein
  • Asian People
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wen, J., Liang, Y., Wang, F., Sun, L., Guo, Y., Duan, X., … Wang, N. (2010). C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population. Clin Chim Acta, 411(3–4), 198–203. https://doi.org/10.1016/j.cca.2009.11.002
Wen, Jiangping, Yuanbo Liang, Fenghua Wang, Lanping Sun, Yongjun Guo, Xinrong Duan, Xiangyi Liu, Tien Yin Wong, Xinxin Lu, and Ningli Wang. “C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population.Clin Chim Acta 411, no. 3–4 (February 2010): 198–203. https://doi.org/10.1016/j.cca.2009.11.002.
Wen J, Liang Y, Wang F, Sun L, Guo Y, Duan X, et al. C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population. Clin Chim Acta. 2010 Feb;411(3–4):198–203.
Wen, Jiangping, et al. “C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population.Clin Chim Acta, vol. 411, no. 3–4, Feb. 2010, pp. 198–203. Pubmed, doi:10.1016/j.cca.2009.11.002.
Wen J, Liang Y, Wang F, Sun L, Guo Y, Duan X, Liu X, Wong TY, Lu X, Wang N. C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population. Clin Chim Acta. 2010 Feb;411(3–4):198–203.
Journal cover image

Published In

Clin Chim Acta

DOI

EISSN

1873-3492

Publication Date

February 2010

Volume

411

Issue

3-4

Start / End Page

198 / 203

Location

Netherlands

Related Subject Headings

  • gamma-Glutamyltransferase
  • Risk Factors
  • Middle Aged
  • Humans
  • General Clinical Medicine
  • Female
  • Diabetes Mellitus, Type 2
  • China
  • C-Reactive Protein
  • Asian People