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Retinal microvascular signs may provide clues to the underlying vasculopathy in patients with deep intracerebral hemorrhage.

Publication ,  Journal Article
Baker, ML; Hand, PJ; Liew, G; Wong, TY; Rochtchina, E; Mitchell, P; Lindley, RI; Hankey, GJ; Wang, JJ; Multi-Centre Retinal Stroke Study Group,
Published in: Stroke
April 2010

BACKGROUND AND PURPOSE: Deep intracerebral hemorrhage (ICH) and lacunar infarcts are the result of small vessel disease, whereas nonlacunar infarcts are often caused by large artery atherosclerosis or cardiac embolism. We hypothesized that patients with deep ICH and lacunar infarcts have similar retinal microvascular signs and that these differ from those seen in patients with nonlacunar infarcts. METHODS: We studied patients with acute stroke and classified their stroke as deep ICH, lacunar infarction, or nonlacunar infarction. In a masked fashion we assessed retinal photographs for quantitative and qualitative evidence of microvascular damage. RESULTS: We recruited 630 patients (51 had deep ICH, 93 had lacunar infarction, and 486 had nonlacunar infarction). Patients with deep ICH were more likely than those with nonlacunar infarcts to have severe focal narrowing of the retinal arterioles (OR, 3.7), severe arteriovenous nicking (OR, 2.6), and quantitatively narrower retinal arterioles and wider retinal venules. Retinal microvascular signs were similar in patients with deep ICH and lacunar infarction. CONCLUSIONS: Patients with deep ICH and lacunar infarcts are more likely than patients with nonlacunar infarcts to have signs indicating hypertensive damage in the retinal arteriolar wall.

Duke Scholars

Published In

Stroke

DOI

EISSN

1524-4628

Publication Date

April 2010

Volume

41

Issue

4

Start / End Page

618 / 623

Location

United States

Related Subject Headings

  • Vascular Diseases
  • Stroke
  • Retinal Vessels
  • Neurology & Neurosurgery
  • Middle Aged
  • Microvessels
  • Male
  • Hypertension
  • Humans
  • Brain Infarction
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Baker, M. L., Hand, P. J., Liew, G., Wong, T. Y., Rochtchina, E., Mitchell, P., … Multi-Centre Retinal Stroke Study Group, . (2010). Retinal microvascular signs may provide clues to the underlying vasculopathy in patients with deep intracerebral hemorrhage. Stroke, 41(4), 618–623. https://doi.org/10.1161/STROKEAHA.109.569764
Baker, Michelle L., Peter J. Hand, Gerald Liew, Tien Y. Wong, Elena Rochtchina, Paul Mitchell, Richard I. Lindley, Graeme J. Hankey, Jie Jin Wang, and Jie Jin Multi-Centre Retinal Stroke Study Group. “Retinal microvascular signs may provide clues to the underlying vasculopathy in patients with deep intracerebral hemorrhage.Stroke 41, no. 4 (April 2010): 618–23. https://doi.org/10.1161/STROKEAHA.109.569764.
Baker ML, Hand PJ, Liew G, Wong TY, Rochtchina E, Mitchell P, et al. Retinal microvascular signs may provide clues to the underlying vasculopathy in patients with deep intracerebral hemorrhage. Stroke. 2010 Apr;41(4):618–23.
Baker, Michelle L., et al. “Retinal microvascular signs may provide clues to the underlying vasculopathy in patients with deep intracerebral hemorrhage.Stroke, vol. 41, no. 4, Apr. 2010, pp. 618–23. Pubmed, doi:10.1161/STROKEAHA.109.569764.
Baker ML, Hand PJ, Liew G, Wong TY, Rochtchina E, Mitchell P, Lindley RI, Hankey GJ, Wang JJ, Multi-Centre Retinal Stroke Study Group. Retinal microvascular signs may provide clues to the underlying vasculopathy in patients with deep intracerebral hemorrhage. Stroke. 2010 Apr;41(4):618–623.

Published In

Stroke

DOI

EISSN

1524-4628

Publication Date

April 2010

Volume

41

Issue

4

Start / End Page

618 / 623

Location

United States

Related Subject Headings

  • Vascular Diseases
  • Stroke
  • Retinal Vessels
  • Neurology & Neurosurgery
  • Middle Aged
  • Microvessels
  • Male
  • Hypertension
  • Humans
  • Brain Infarction