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Risk prediction of coronary heart disease based on retinal vascular caliber (from the Atherosclerosis Risk In Communities [ARIC] Study).

Publication ,  Journal Article
McGeechan, K; Liew, G; Macaskill, P; Irwig, L; Klein, R; Sharrett, AR; Klein, BEK; Wang, JJ; Chambless, LE; Wong, TY
Published in: Am J Cardiol
July 1, 2008

Recent studies showed that such retinal vascular signs as quantitative retinal vascular caliber were associated with increased risk of incident coronary heart disease (CHD), but whether these retinal vascular signs add to the prediction of CHD over and above traditional CHD risk factors was not addressed. Whether these signs add to the prediction of CHD over and above the Framingham risk score in people (n = 9,155) without diabetes selected from the ARIC Study was investigated. Incident CHD was ascertained using standardized methods, and retinal vascular caliber and other retinal signs were measured from retinal photographs. After a mean of 8.8 years of follow-up, there were 700 incident CHD events. Women with wider retinal venular caliber (hazard ratio 1.27/1-SD increase, 95% confidence interval 1.08 to 1.50) and narrower retinal arteriolar caliber (hazard ratio 1.31/1-SD decrease, 95% confidence interval 1.10 to 1.56) had a higher risk of incident CHD after adjusting for Framingham risk score variables. Area under the receiver operator characteristic curve increased from 0.695 to 0.706 (1.7% increase) with the addition of retinal vascular caliber to the Framingham risk model. Risk prediction models with and without retinal vascular caliber both fitted the data and were well calibrated for women. In men, retinal vascular caliber was not associated with CHD risk after adjustment. Other retinal vascular signs were not associated with 10-year incident CHD in men or women. In conclusion, although retinal vascular caliber independently predicted CHD risk in women, the incremental predictive ability over that of the Framingham model was modest and unlikely to translate meaningfully into clinical practice.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

July 1, 2008

Volume

102

Issue

1

Start / End Page

58 / 63

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Retinal Vessels
  • Retinal Diseases
  • Predictive Value of Tests
  • Photography
  • Middle Aged
  • Male
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McGeechan, K., Liew, G., Macaskill, P., Irwig, L., Klein, R., Sharrett, A. R., … Wong, T. Y. (2008). Risk prediction of coronary heart disease based on retinal vascular caliber (from the Atherosclerosis Risk In Communities [ARIC] Study). Am J Cardiol, 102(1), 58–63. https://doi.org/10.1016/j.amjcard.2008.02.094
McGeechan, Kevin, Gerald Liew, Petra Macaskill, Les Irwig, Ronald Klein, A Richey Sharrett, Barbara E. K. Klein, Jie J. Wang, Lloyd E. Chambless, and Tien Y. Wong. “Risk prediction of coronary heart disease based on retinal vascular caliber (from the Atherosclerosis Risk In Communities [ARIC] Study).Am J Cardiol 102, no. 1 (July 1, 2008): 58–63. https://doi.org/10.1016/j.amjcard.2008.02.094.
McGeechan K, Liew G, Macaskill P, Irwig L, Klein R, Sharrett AR, et al. Risk prediction of coronary heart disease based on retinal vascular caliber (from the Atherosclerosis Risk In Communities [ARIC] Study). Am J Cardiol. 2008 Jul 1;102(1):58–63.
McGeechan, Kevin, et al. “Risk prediction of coronary heart disease based on retinal vascular caliber (from the Atherosclerosis Risk In Communities [ARIC] Study).Am J Cardiol, vol. 102, no. 1, July 2008, pp. 58–63. Pubmed, doi:10.1016/j.amjcard.2008.02.094.
McGeechan K, Liew G, Macaskill P, Irwig L, Klein R, Sharrett AR, Klein BEK, Wang JJ, Chambless LE, Wong TY. Risk prediction of coronary heart disease based on retinal vascular caliber (from the Atherosclerosis Risk In Communities [ARIC] Study). Am J Cardiol. 2008 Jul 1;102(1):58–63.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

July 1, 2008

Volume

102

Issue

1

Start / End Page

58 / 63

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Retinal Vessels
  • Retinal Diseases
  • Predictive Value of Tests
  • Photography
  • Middle Aged
  • Male
  • Humans
  • Female