Scholars@Duke

Convex hull based neuro-retinal optic cup ellipse optimization in glaucoma diagnosis.

Publication ,  Conference
Zhang, Z; Liu, J; Cherian, NS; Sun, Y; Lim, JH; Wong, WK; Tan, NM; Lu, S; Li, H; Wong, TY
Published in: Annu Int Conf IEEE Eng Med Biol Soc
2009
Published version (DOI) Link to item

Glaucoma is the second leading cause of blindness. Glaucoma can be diagnosed through measurement of neuro-retinal optic cup-to-disc ratio (CDR). Automatic calculation of optic cup boundary is challenging due to the interweavement of blood vessels with the surrounding tissues around the cup. A Convex Hull based Neuro-Retinal Optic Cup Ellipse Optimization algorithm improves the accuracy of the boundary estimation. The algorithm's effectiveness is demonstrated on 70 clinical patient's data set collected from Singapore Eye Research Institute. The root mean squared error of the new algorithm is 43% better than the ARGALI system which is the state-of-the-art. This further leads to a large clinical evaluation of the algorithm involving 15 thousand patients from Australia and Singapore.

Duke Scholars

Tien Yin Wong
Author Tien Yin Wong Ophthalmology
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Published In

Annu Int Conf IEEE Eng Med Biol Soc

DOI

10.1109/IEMBS.2009.5332913

ISSN

2375-7477

Publication Date

2009

Volume

2009

Start / End Page

1441 / 1444

Location

United States

Related Subject Headings

  • Optic Disk
  • Least-Squares Analysis
  • Image Processing, Computer-Assisted
  • Humans
  • Glaucoma
  • Diagnostic Techniques, Ophthalmological
  • Biomedical Engineering
  • Algorithms
 

Citation

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Zhang, Z., Liu, J., Cherian, N. S., Sun, Y., Lim, J. H., Wong, W. K., … Wong, T. Y. (2009). Convex hull based neuro-retinal optic cup ellipse optimization in glaucoma diagnosis. In Annu Int Conf IEEE Eng Med Biol Soc (Vol. 2009, pp. 1441–1444). United States. https://doi.org/10.1109/IEMBS.2009.5332913
Zhang, Zhuo, Jiang Liu, Neetu Sara Cherian, Ying Sun, Joo Hwee Lim, Wing Kee Wong, Ngan Meng Tan, Shijian Lu, Huiqi Li, and Tien Ying Wong. “Convex hull based neuro-retinal optic cup ellipse optimization in glaucoma diagnosis.” In Annu Int Conf IEEE Eng Med Biol Soc, 2009:1441–44, 2009. https://doi.org/10.1109/IEMBS.2009.5332913.
Zhang Z, Liu J, Cherian NS, Sun Y, Lim JH, Wong WK, et al. Convex hull based neuro-retinal optic cup ellipse optimization in glaucoma diagnosis. In: Annu Int Conf IEEE Eng Med Biol Soc. 2009. p. 1441–4.
Zhang, Zhuo, et al. “Convex hull based neuro-retinal optic cup ellipse optimization in glaucoma diagnosis.” Annu Int Conf IEEE Eng Med Biol Soc, vol. 2009, 2009, pp. 1441–44. Pubmed, doi:10.1109/IEMBS.2009.5332913.
Zhang Z, Liu J, Cherian NS, Sun Y, Lim JH, Wong WK, Tan NM, Lu S, Li H, Wong TY. Convex hull based neuro-retinal optic cup ellipse optimization in glaucoma diagnosis. Annu Int Conf IEEE Eng Med Biol Soc. 2009. p. 1441–1444.

Published In

Annu Int Conf IEEE Eng Med Biol Soc

DOI

10.1109/IEMBS.2009.5332913

ISSN

2375-7477

Publication Date

2009

Volume

2009

Start / End Page

1441 / 1444

Location

United States

Related Subject Headings

  • Optic Disk
  • Least-Squares Analysis
  • Image Processing, Computer-Assisted
  • Humans
  • Glaucoma
  • Diagnostic Techniques, Ophthalmological
  • Biomedical Engineering
  • Algorithms