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Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis.

Publication ,  Journal Article
Chong, EW-T; Wong, TY; Kreis, AJ; Simpson, JA; Guymer, RH
Published in: BMJ
October 13, 2007

OBJECTIVE: To evaluate the effectiveness of dietary antioxidants in the primary prevention of age related macular degeneration (AMD). DESIGN: Systematic review and meta-analysis. DATA SOURCES: Search of seven databases without limits on year or language of publication, and retrieval of references in pertinent reviews and articles. METHODS: Two reviewers independently searched the databases and selected the studies, using standardised criteria. Randomised clinical trials and prospective cohort studies were included. Of the 4192 abstracts initially identified, 12 studies (nine prospective cohort studies and three randomised clinical trials) met the selection criteria and were included. Data extraction and study quality evaluation were independently reviewed, using standardised criteria. Results were pooled quantitatively using meta-analytic methods. RESULTS: The nine prospective cohort studies included 149 203 people, with 1878 incident cases of early AMD. The antioxidants investigated differed across studies, and not all studies contributed to the meta-analysis of each antioxidant. Pooled results from prospective cohort studies indicated that vitamin A, vitamin C, vitamin E, zinc, lutein, zeaxanthin, alpha carotene, beta carotene, beta cryptoxanthin, and lycopene have little or no effect in the primary prevention of early AMD. The three randomised clinical trials did not show that antioxidant supplements prevented early AMD. CONCLUSIONS: There is insufficient evidence to support the role of dietary antioxidants, including the use of dietary antioxidant supplements, for the primary prevention of early AMD.

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Published In

BMJ

DOI

EISSN

1756-1833

Publication Date

October 13, 2007

Volume

335

Issue

7623

Start / End Page

755

Location

England

Related Subject Headings

  • Treatment Failure
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Macular Degeneration
  • Humans
  • General & Internal Medicine
  • Cohort Studies
  • Antioxidants
  • 52 Psychology
  • 42 Health sciences
 

Citation

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Chong, E.-T., Wong, T. Y., Kreis, A. J., Simpson, J. A., & Guymer, R. H. (2007). Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. BMJ, 335(7623), 755. https://doi.org/10.1136/bmj.39350.500428.47
Chong, Elaine W-T, Tien Y. Wong, Andreas J. Kreis, Julie A. Simpson, and Robyn H. Guymer. “Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis.BMJ 335, no. 7623 (October 13, 2007): 755. https://doi.org/10.1136/bmj.39350.500428.47.
Chong EW-T, Wong TY, Kreis AJ, Simpson JA, Guymer RH. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. BMJ. 2007 Oct 13;335(7623):755.
Chong, Elaine W. T., et al. “Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis.BMJ, vol. 335, no. 7623, Oct. 2007, p. 755. Pubmed, doi:10.1136/bmj.39350.500428.47.
Chong EW-T, Wong TY, Kreis AJ, Simpson JA, Guymer RH. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. BMJ. 2007 Oct 13;335(7623):755.

Published In

BMJ

DOI

EISSN

1756-1833

Publication Date

October 13, 2007

Volume

335

Issue

7623

Start / End Page

755

Location

England

Related Subject Headings

  • Treatment Failure
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Macular Degeneration
  • Humans
  • General & Internal Medicine
  • Cohort Studies
  • Antioxidants
  • 52 Psychology
  • 42 Health sciences