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Efficacy and safety of multiple intravitreal triamcinolone injections for refractory diabetic macular oedema.

Publication ,  Journal Article
Gillies, MC; Islam, FMA; Zhu, M; Larsson, J; Wong, TY
Published in: Br J Ophthalmol
October 2007

AIM: The efficacy and safety of repeated injections of intravitreal triamcinolone (IVTA) for diabetic macular oedema is unclear, with results of previous reports conflicting. METHODS: This is a prospective, observational case series of 27 eyes receiving IVTA for diabetic macular oedema. LogMAR visual acuity (VA) and central macular thickness (CMT) were measured at baseline and in 3 to 6 monthly intervals for up to 24 months, then correlated with the number of IVTA injections given. RESULTS: One IVTA injection was required in 6 (18%) eyes, 2 in 8 (24%) eyes, 3 in 13 (39%) eyes and 4-5 in 6 (18%) eyes. VA improved in all patients, but neither the final improvement in VA nor the absolute improvement in CMT from baseline to 24 months correlated with the number of injections received (p = 0.44 and 0.84, respectively). Cataract surgery was more frequent in eyes receiving more injections (p = 0.01). CONCLUSIONS: This study suggests that repeated injections of IVTA continue to be as effective as the first over a 2-year period. The probability of cataract surgery increases with an increasing number of injections.

Duke Scholars

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

October 2007

Volume

91

Issue

10

Start / End Page

1323 / 1326

Location

England

Related Subject Headings

  • Vitreous Body
  • Visual Acuity
  • Triamcinolone
  • Treatment Outcome
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Edema
  • Macula Lutea
 

Citation

APA
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ICMJE
MLA
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Gillies, M. C., Islam, F. M. A., Zhu, M., Larsson, J., & Wong, T. Y. (2007). Efficacy and safety of multiple intravitreal triamcinolone injections for refractory diabetic macular oedema. Br J Ophthalmol, 91(10), 1323–1326. https://doi.org/10.1136/bjo.2006.113167
Gillies, Mark C., FM Amirul Islam, Meidong Zhu, Jorgen Larsson, and Tien Y. Wong. “Efficacy and safety of multiple intravitreal triamcinolone injections for refractory diabetic macular oedema.Br J Ophthalmol 91, no. 10 (October 2007): 1323–26. https://doi.org/10.1136/bjo.2006.113167.
Gillies MC, Islam FMA, Zhu M, Larsson J, Wong TY. Efficacy and safety of multiple intravitreal triamcinolone injections for refractory diabetic macular oedema. Br J Ophthalmol. 2007 Oct;91(10):1323–6.
Gillies, Mark C., et al. “Efficacy and safety of multiple intravitreal triamcinolone injections for refractory diabetic macular oedema.Br J Ophthalmol, vol. 91, no. 10, Oct. 2007, pp. 1323–26. Pubmed, doi:10.1136/bjo.2006.113167.
Gillies MC, Islam FMA, Zhu M, Larsson J, Wong TY. Efficacy and safety of multiple intravitreal triamcinolone injections for refractory diabetic macular oedema. Br J Ophthalmol. 2007 Oct;91(10):1323–1326.

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

October 2007

Volume

91

Issue

10

Start / End Page

1323 / 1326

Location

England

Related Subject Headings

  • Vitreous Body
  • Visual Acuity
  • Triamcinolone
  • Treatment Outcome
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Edema
  • Macula Lutea