Skip to main content

Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study.

Publication ,  Journal Article
Tikellis, G; Sun, C; Gorin, MB; Klein, R; Klein, BEK; Larsen, EKM; Siscovick, DS; Hubbard, LD; Wong, TY
Published in: Arch Ophthalmol
January 2007

OBJECTIVE: To examine the association between the apolipoprotein E (APOE) gene and age-related maculopathy (ARM) in an older population. METHODS: Two thousand one hundred seventy persons 65 years and older sampled from 4 US communities had ARM signs assessed from retinal photographs using a modified Wisconsin Age-Related Maculopathy Grading System. DNA extracted from blood samples was analyzed for common APOE alleles. RESULTS: After controlling for age, sex, cigarette smoking, and other factors, white participants carrying the epsilon2 allele had an increased risk of late ARM (odds ratio, 2.53 [95% confidence interval, 1.08-5.90]) while carriers of the epsilon4 allele had a lower risk of late ARM (odds ratio, 0.69 [95% confidence interval, 0.19-2.50]). There were too few late ARM cases in African American individuals for analysis. CONCLUSION: APOE polymorphism is associated with late ARM in older white persons 65 years and older. Consistent with previous studies, the APOE epsilon2 allele is associated with a significant increased risk of late ARM development, whereas the epsilon4 allele may confer some protection.

Duke Scholars

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

January 2007

Volume

125

Issue

1

Start / End Page

68 / 73

Location

United States

Related Subject Headings

  • White People
  • Risk Factors
  • Polymorphism, Genetic
  • Ophthalmology & Optometry
  • Odds Ratio
  • Male
  • Macular Degeneration
  • Humans
  • Genotype
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tikellis, G., Sun, C., Gorin, M. B., Klein, R., Klein, B. E. K., Larsen, E. K. M., … Wong, T. Y. (2007). Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study. Arch Ophthalmol, 125(1), 68–73. https://doi.org/10.1001/archopht.125.1.68
Tikellis, Gabriella, Cong Sun, Michael B. Gorin, Ronald Klein, Barbara E. K. Klein, Emily K Marino Larsen, David S. Siscovick, Larry D. Hubbard, and Tien Y. Wong. “Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study.Arch Ophthalmol 125, no. 1 (January 2007): 68–73. https://doi.org/10.1001/archopht.125.1.68.
Tikellis G, Sun C, Gorin MB, Klein R, Klein BEK, Larsen EKM, et al. Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study. Arch Ophthalmol. 2007 Jan;125(1):68–73.
Tikellis, Gabriella, et al. “Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study.Arch Ophthalmol, vol. 125, no. 1, Jan. 2007, pp. 68–73. Pubmed, doi:10.1001/archopht.125.1.68.
Tikellis G, Sun C, Gorin MB, Klein R, Klein BEK, Larsen EKM, Siscovick DS, Hubbard LD, Wong TY. Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study. Arch Ophthalmol. 2007 Jan;125(1):68–73.

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

January 2007

Volume

125

Issue

1

Start / End Page

68 / 73

Location

United States

Related Subject Headings

  • White People
  • Risk Factors
  • Polymorphism, Genetic
  • Ophthalmology & Optometry
  • Odds Ratio
  • Male
  • Macular Degeneration
  • Humans
  • Genotype
  • Female