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Fractal analysis of the retinal vasculature and chronic kidney disease.

Publication ,  Journal Article
Sng, CCA; Sabanayagam, C; Lamoureux, EL; Liu, E; Lim, SC; Hamzah, H; Lee, J; Tai, ES; Wong, TY
Published in: Nephrol Dial Transplant
July 2010

BACKGROUND. Fractal analysis provides a global index of the geometric complexity and optimality of vascular networks. In this study, we investigated the relationship between fractal measurements of the retinal vasculature and chronic kidney disease (CKD). METHODS. This was a population-based case-control study which included participants from the Singapore Prospective Study Program. We identified 261 participants with CKD, defined as estimated glomerular filtration rate of <60 mL/min/1.73 m(2), and 651 controls. The retinal fractal dimension (D(f)) was quantified from digitized fundus photographs using a computer-based programme. RESULTS. The mean D(f) was 1.43 +/- 0.048 in the participants with CKD and 1.44 +/- 0.042 in controls (P = 0.013). Suboptimal D(f) in the lowest (first) and highest (fifth) quintiles were associated with an increased prevalence of CKD after adjusting for age, systolic blood pressure, diabetes and other risk factors [odds ratio (OR) 2.10, 95% confidence interval (CI) 1.15, 3.83 and OR 1.84, 95% CI 1.06, 3.17; compared to the fourth quintile, respectively). This association was present even in participants without diabetes or hypertension. CONCLUSIONS. Our study found that an abnormal retinal vascular network is associated with an increased risk of CKD, supporting the hypothesis that deviations from optimal microvascular architecture may be related to kidney damage.

Duke Scholars

Published In

Nephrol Dial Transplant

DOI

EISSN

1460-2385

Publication Date

July 2010

Volume

25

Issue

7

Start / End Page

2252 / 2258

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Singapore
  • Risk Factors
  • Retinal Artery
  • Middle Aged
  • Male
  • Kidney Diseases
  • Image Processing, Computer-Assisted
  • Humans
  • Glomerular Filtration Rate
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sng, C. C. A., Sabanayagam, C., Lamoureux, E. L., Liu, E., Lim, S. C., Hamzah, H., … Wong, T. Y. (2010). Fractal analysis of the retinal vasculature and chronic kidney disease. Nephrol Dial Transplant, 25(7), 2252–2258. https://doi.org/10.1093/ndt/gfq007
Sng, Chelvin C. A., Charumathi Sabanayagam, Ecosse L. Lamoureux, Erica Liu, Su Chi Lim, Haslina Hamzah, Jeannette Lee, E Shyong Tai, and Tien Y. Wong. “Fractal analysis of the retinal vasculature and chronic kidney disease.Nephrol Dial Transplant 25, no. 7 (July 2010): 2252–58. https://doi.org/10.1093/ndt/gfq007.
Sng CCA, Sabanayagam C, Lamoureux EL, Liu E, Lim SC, Hamzah H, et al. Fractal analysis of the retinal vasculature and chronic kidney disease. Nephrol Dial Transplant. 2010 Jul;25(7):2252–8.
Sng, Chelvin C. A., et al. “Fractal analysis of the retinal vasculature and chronic kidney disease.Nephrol Dial Transplant, vol. 25, no. 7, July 2010, pp. 2252–58. Pubmed, doi:10.1093/ndt/gfq007.
Sng CCA, Sabanayagam C, Lamoureux EL, Liu E, Lim SC, Hamzah H, Lee J, Tai ES, Wong TY. Fractal analysis of the retinal vasculature and chronic kidney disease. Nephrol Dial Transplant. 2010 Jul;25(7):2252–2258.
Journal cover image

Published In

Nephrol Dial Transplant

DOI

EISSN

1460-2385

Publication Date

July 2010

Volume

25

Issue

7

Start / End Page

2252 / 2258

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Singapore
  • Risk Factors
  • Retinal Artery
  • Middle Aged
  • Male
  • Kidney Diseases
  • Image Processing, Computer-Assisted
  • Humans
  • Glomerular Filtration Rate