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Natural history of branch retinal vein occlusion: an evidence-based systematic review.

Publication ,  Journal Article
Rogers, SL; McIntosh, RL; Lim, L; Mitchell, P; Cheung, N; Kowalski, JW; Nguyen, HP; Wang, JJ; Wong, TY
Published in: Ophthalmology
June 2010

OBJECTIVE: To describe the natural history of branch retinal vein occlusion (BRVO) based on the best available evidence from the literature. CLINICAL RELEVANCE: Branch retinal vein occlusion is the second most frequent major retinal vascular disease. Although several new treatments for BRVO are currently being introduced, data on its natural history are sparse. METHODS: English language articles were retrieved using a keyword search of MEDLINE, EMBASE, Current Contents, and the Cochrane Library to November 13, 2008, supplemented by manually searching the references of review articles published within the last 5 years. All relevant observational studies evaluating the natural history of BRVO and all clinical trials evaluating BRVO interventions with an untreated control arm were independently identified by 2 investigators. RESULTS: Of a total of 5965 citations retrieved, 24 eligible studies were identified and reviewed, providing 1608 eyes with BRVO with data on natural history. Visual acuity (VA) was moderately poor at baseline (<20/40). Although VA generally improved, with mean improvement ranging from 1 letter at 6 weeks to 28 letters up to 24 months, few studies reported improvement beyond 20/40. Over a 1-year period, 5% to 15% of eyes developed macular edema (ME), but of those with ME at baseline, 18% to 41% resolved. At baseline, 5% to 6% of eyes had bilateral BRVO, with 10% developing fellow eye involvement over time. There were few high-quality studies on other outcomes, including development of new vessels. CONCLUSIONS: Visual acuity generally improved in eyes with BRVO without intervention, although clinically significant improvement beyond 20/40 was uncommon.

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Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

June 2010

Volume

117

Issue

6

Start / End Page

1094 / 1101.e5

Location

United States

Related Subject Headings

  • Visual Acuity
  • Retinal Vein Occlusion
  • Retinal Vein
  • Ophthalmology & Optometry
  • Humans
  • 3212 Ophthalmology and optometry
  • 1117 Public Health and Health Services
  • 1113 Opthalmology and Optometry
  • 1103 Clinical Sciences
 

Citation

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Rogers, S. L., McIntosh, R. L., Lim, L., Mitchell, P., Cheung, N., Kowalski, J. W., … Wong, T. Y. (2010). Natural history of branch retinal vein occlusion: an evidence-based systematic review. Ophthalmology, 117(6), 1094-1101.e5. https://doi.org/10.1016/j.ophtha.2010.01.058
Rogers, Sophie L., Rachel L. McIntosh, Lyndell Lim, Paul Mitchell, Ning Cheung, Jonathan W. Kowalski, Hiep P. Nguyen, Jie Jin Wang, and Tien Yin Wong. “Natural history of branch retinal vein occlusion: an evidence-based systematic review.Ophthalmology 117, no. 6 (June 2010): 1094-1101.e5. https://doi.org/10.1016/j.ophtha.2010.01.058.
Rogers SL, McIntosh RL, Lim L, Mitchell P, Cheung N, Kowalski JW, et al. Natural history of branch retinal vein occlusion: an evidence-based systematic review. Ophthalmology. 2010 Jun;117(6):1094-1101.e5.
Rogers, Sophie L., et al. “Natural history of branch retinal vein occlusion: an evidence-based systematic review.Ophthalmology, vol. 117, no. 6, June 2010, pp. 1094-1101.e5. Pubmed, doi:10.1016/j.ophtha.2010.01.058.
Rogers SL, McIntosh RL, Lim L, Mitchell P, Cheung N, Kowalski JW, Nguyen HP, Wang JJ, Wong TY. Natural history of branch retinal vein occlusion: an evidence-based systematic review. Ophthalmology. 2010 Jun;117(6):1094-1101.e5.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

June 2010

Volume

117

Issue

6

Start / End Page

1094 / 1101.e5

Location

United States

Related Subject Headings

  • Visual Acuity
  • Retinal Vein Occlusion
  • Retinal Vein
  • Ophthalmology & Optometry
  • Humans
  • 3212 Ophthalmology and optometry
  • 1117 Public Health and Health Services
  • 1113 Opthalmology and Optometry
  • 1103 Clinical Sciences