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Retinal arteriolar caliber predicts incident retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study.

Publication ,  Journal Article
Rogers, SL; Tikellis, G; Cheung, N; Tapp, R; Shaw, J; Zimmet, PZ; Mitchell, P; Wang, JJ; Wong, TY
Published in: Diabetes Care
April 2008

Changes in retinal vascular caliber may reflect subclinical microvascular disease and provide prognostic information regarding risk of retinopathy. In this study, we examined the prospective association of retinal vascular caliber with retinopathy risk in an Australian population-based cohort. A total of 906 participants without retinopathy at baseline had retinal vascular caliber measured from photographs and were followed-up for 5 years for incident retinopathy. After adjusting for age, sex, systolic blood pressure, A1C, and other risk factors, individuals with wider retinal arteriolar caliber (widest 25% vs. the remaining three-quarters of the population) were more likely to develop incident retinopathy (odds ratio 4.79 [95% CI 1.57-14.58]). This association was not significant in individuals without diabetes. Venular caliber did not predict incident retinopathy. Our findings suggest that retinal arteriolar dilatation is a specific sign of diabetic microvascular dysfunction and may be a preclinical marker of diabetic retinopathy.

Duke Scholars

Published In

Diabetes Care

DOI

EISSN

1935-5548

Publication Date

April 2008

Volume

31

Issue

4

Start / End Page

761 / 763

Location

United States

Related Subject Headings

  • Retinal Artery
  • Odds Ratio
  • Multivariate Analysis
  • Male
  • Incidence
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diabetic Retinopathy
  • Blood Pressure
 

Citation

APA
Chicago
ICMJE
MLA
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Rogers, S. L., Tikellis, G., Cheung, N., Tapp, R., Shaw, J., Zimmet, P. Z., … Wong, T. Y. (2008). Retinal arteriolar caliber predicts incident retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study. Diabetes Care, 31(4), 761–763. https://doi.org/10.2337/dc07-1622
Rogers, Sophie Louise, Gabriella Tikellis, Ning Cheung, Robyn Tapp, Jonathan Shaw, Paul Z. Zimmet, Paul Mitchell, Jie Jin Wang, and Tien Yin Wong. “Retinal arteriolar caliber predicts incident retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study.Diabetes Care 31, no. 4 (April 2008): 761–63. https://doi.org/10.2337/dc07-1622.
Rogers SL, Tikellis G, Cheung N, Tapp R, Shaw J, Zimmet PZ, et al. Retinal arteriolar caliber predicts incident retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study. Diabetes Care. 2008 Apr;31(4):761–3.
Rogers, Sophie Louise, et al. “Retinal arteriolar caliber predicts incident retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study.Diabetes Care, vol. 31, no. 4, Apr. 2008, pp. 761–63. Pubmed, doi:10.2337/dc07-1622.
Rogers SL, Tikellis G, Cheung N, Tapp R, Shaw J, Zimmet PZ, Mitchell P, Wang JJ, Wong TY. Retinal arteriolar caliber predicts incident retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study. Diabetes Care. 2008 Apr;31(4):761–763.

Published In

Diabetes Care

DOI

EISSN

1935-5548

Publication Date

April 2008

Volume

31

Issue

4

Start / End Page

761 / 763

Location

United States

Related Subject Headings

  • Retinal Artery
  • Odds Ratio
  • Multivariate Analysis
  • Male
  • Incidence
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diabetic Retinopathy
  • Blood Pressure