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Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA).

Publication ,  Journal Article
Nguyen, TT; Wang, JJ; Sharrett, AR; Islam, FMA; Klein, R; Klein, BEK; Cotch, MF; Wong, TY
Published in: Diabetes Care
March 2008

OBJECTIVE: To examine the relationship of retinal vascular caliber with diabetes, glycemia, and diabetic retinopathy. RESEARCH DESIGN AND METHODS: Population-based study using data from the Multi-Ethnic Study of Atherosclerosis (MESA), comprising 5,976 individuals (whites, blacks, Hispanics, and Chinese) residing in six U.S. communities who were free of clinical cardiovascular disease at baseline. Retinal vascular caliber was measured from digital retinal photographs. RESULTS: There were 4,585 individuals with normal fasting glucose (NFG), 499 with impaired fasting glucose (IFG), 165 with diabetes with retinopathy signs, and 727 with diabetes without retinopathy signs. After multivariate analysis, retinal arteriolar caliber increased from 143.8 microm in subjects with NFG to 144.5 microm in IFG and 146.1 microm in diabetes (P < 0.001 for trend). Retinal venular caliber increased from 214.4 microm in NFG to 216.7 microm in IFG and 218.0 microm in diabetes (P < 0.001 for trend). Retinal venular caliber was significantly larger with increasing levels of fasting glucose and A1C. In a subgroup analysis by ethnicity, the association between wider arteriolar caliber and diabetes was evident in whites only, whereas wider venular caliber and diabetes was evident in Hispanics and Chinese only. In people with diabetes, eyes with retinopathy had larger retinal venular but not arteriolar caliber. CONCLUSIONS: Retinal arteriolar and venular calibers are larger in individuals with diabetes, but the pattern of associations appears to vary by ethnicity. Retinal venular caliber is additionally associated with retinopathy signs. These findings add further to the concept that variations in retinal vascular caliber may reflect early diabetic microvascular damage.

Duke Scholars

Published In

Diabetes Care

DOI

EISSN

1935-5548

Publication Date

March 2008

Volume

31

Issue

3

Start / End Page

544 / 549

Location

United States

Related Subject Headings

  • White People
  • Retinal Vessels
  • Retinal Diseases
  • Middle Aged
  • Male
  • Humans
  • Hispanic or Latino
  • Glycated Hemoglobin
  • Glucose Intolerance
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nguyen, T. T., Wang, J. J., Sharrett, A. R., Islam, F. M. A., Klein, R., Klein, B. E. K., … Wong, T. Y. (2008). Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care, 31(3), 544–549. https://doi.org/10.2337/dc07-1528
Nguyen, Thanh Tan, Jie Jin Wang, A Richey Sharrett, FM Amirul Islam, Ronald Klein, Barbara E. K. Klein, Mary Frances Cotch, and Tien Yin Wong. “Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA).Diabetes Care 31, no. 3 (March 2008): 544–49. https://doi.org/10.2337/dc07-1528.
Nguyen TT, Wang JJ, Sharrett AR, Islam FMA, Klein R, Klein BEK, et al. Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care. 2008 Mar;31(3):544–9.
Nguyen, Thanh Tan, et al. “Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA).Diabetes Care, vol. 31, no. 3, Mar. 2008, pp. 544–49. Pubmed, doi:10.2337/dc07-1528.
Nguyen TT, Wang JJ, Sharrett AR, Islam FMA, Klein R, Klein BEK, Cotch MF, Wong TY. Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care. 2008 Mar;31(3):544–549.

Published In

Diabetes Care

DOI

EISSN

1935-5548

Publication Date

March 2008

Volume

31

Issue

3

Start / End Page

544 / 549

Location

United States

Related Subject Headings

  • White People
  • Retinal Vessels
  • Retinal Diseases
  • Middle Aged
  • Male
  • Humans
  • Hispanic or Latino
  • Glycated Hemoglobin
  • Glucose Intolerance
  • Female