Tristetraprolin as a Therapeutic Target in Inflammatory Disease.
Members of the tristetraprolin (TTP) family of RNA-binding proteins are found in all major eukaryotic groups. TTP family members, from plants through humans, can bind adenosine-uridine rich elements in target mRNAs with high affinity. In mammalian cells, these proteins then promote deadenylation and decay of target transcripts. Four such proteins are found in mice, of which the best studied is TTP. When the gene encoding TTP is disrupted in mice, the animals develop a severe syndrome of arthritis, autoimmunity, cachexia, dermatitis, and myeloid hyperplasia. Conversely, recent overexpression studies have demonstrated protection against several experimental models of immune inflammatory disease. This endogenous anti-inflammatory protein could serve as the basis for novel approaches to therapy of similar conditions in humans.
Duke Scholars
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- Tristetraprolin
- RNA, Messenger
- Pharmacology & Pharmacy
- Mice
- Inflammation
- Humans
- Drug Design
- Disease Models, Animal
- Autoimmune Diseases
- Anti-Inflammatory Agents
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tristetraprolin
- RNA, Messenger
- Pharmacology & Pharmacy
- Mice
- Inflammation
- Humans
- Drug Design
- Disease Models, Animal
- Autoimmune Diseases
- Anti-Inflammatory Agents