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Tristetraprolin as a Therapeutic Target in Inflammatory Disease.

Publication ,  Journal Article
Patial, S; Blackshear, PJ
Published in: Trends Pharmacol Sci
October 2016

Members of the tristetraprolin (TTP) family of RNA-binding proteins are found in all major eukaryotic groups. TTP family members, from plants through humans, can bind adenosine-uridine rich elements in target mRNAs with high affinity. In mammalian cells, these proteins then promote deadenylation and decay of target transcripts. Four such proteins are found in mice, of which the best studied is TTP. When the gene encoding TTP is disrupted in mice, the animals develop a severe syndrome of arthritis, autoimmunity, cachexia, dermatitis, and myeloid hyperplasia. Conversely, recent overexpression studies have demonstrated protection against several experimental models of immune inflammatory disease. This endogenous anti-inflammatory protein could serve as the basis for novel approaches to therapy of similar conditions in humans.

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Published In

Trends Pharmacol Sci

DOI

EISSN

1873-3735

Publication Date

October 2016

Volume

37

Issue

10

Start / End Page

811 / 821

Location

England

Related Subject Headings

  • Tristetraprolin
  • RNA, Messenger
  • Pharmacology & Pharmacy
  • Mice
  • Inflammation
  • Humans
  • Drug Design
  • Disease Models, Animal
  • Autoimmune Diseases
  • Anti-Inflammatory Agents
 

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Patial, S., & Blackshear, P. J. (2016). Tristetraprolin as a Therapeutic Target in Inflammatory Disease. Trends Pharmacol Sci, 37(10), 811–821. https://doi.org/10.1016/j.tips.2016.07.002
Patial, Sonika, and Perry J. Blackshear. “Tristetraprolin as a Therapeutic Target in Inflammatory Disease.Trends Pharmacol Sci 37, no. 10 (October 2016): 811–21. https://doi.org/10.1016/j.tips.2016.07.002.
Patial S, Blackshear PJ. Tristetraprolin as a Therapeutic Target in Inflammatory Disease. Trends Pharmacol Sci. 2016 Oct;37(10):811–21.
Patial, Sonika, and Perry J. Blackshear. “Tristetraprolin as a Therapeutic Target in Inflammatory Disease.Trends Pharmacol Sci, vol. 37, no. 10, Oct. 2016, pp. 811–21. Pubmed, doi:10.1016/j.tips.2016.07.002.
Patial S, Blackshear PJ. Tristetraprolin as a Therapeutic Target in Inflammatory Disease. Trends Pharmacol Sci. 2016 Oct;37(10):811–821.
Journal cover image

Published In

Trends Pharmacol Sci

DOI

EISSN

1873-3735

Publication Date

October 2016

Volume

37

Issue

10

Start / End Page

811 / 821

Location

England

Related Subject Headings

  • Tristetraprolin
  • RNA, Messenger
  • Pharmacology & Pharmacy
  • Mice
  • Inflammation
  • Humans
  • Drug Design
  • Disease Models, Animal
  • Autoimmune Diseases
  • Anti-Inflammatory Agents