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Serum insulin-like growth factor-1 and its binding protein-7: potential novel biomarkers for heart failure with preserved ejection fraction.

Publication ,  Journal Article
Barroso, MC; Kramer, F; Greene, SJ; Scheyer, D; Köhler, T; Karoff, M; Seyfarth, M; Gheorghiade, M; Dinh, W
Published in: BMC Cardiovasc Disord
October 21, 2016

BACKGROUND: Insulin-like growth factor binding protein-7 (IGFBP-7) modulates the biological activities of insulin-like growth factor-1 (IGF-1). Previous studies demonstrated the prognostic value of IGFBP-7 and IGF-1 among patients with systolic heart failure (HF). This study aimed to evaluate the IGF1/IGFBP-7 axis in HF patients with preserved ejection fraction (HFpEF). METHODS: Serum IGF-1 and IGFBP-7 levels were measured in 300 eligible consecutive patients who underwent comprehensive cardiac assessment. Patients were categorized into 3 groups including controls with normal diastolic function (n = 55), asymptomatic left ventricular diastolic dysfunction (LVDD, n = 168) and HFpEF (n = 77). RESULTS: IGFBP-7 serum levels showed a significant graded increase from controls to LVDD to HFpEF (median 50.30 [43.1-55.3] vs. 54.40 [48.15-63.40] vs. 61.9 [51.6-69.7], respectively, P < 0.001), whereas IGF-1 levels showed a graded decline from controls to LVDD to HFpEF (120.0 [100.8-144.0] vs. 112.3 [88.8-137.1] vs. 99.5 [72.2-124.4], p < 0.001). The IGFBP-7/IGF-1 ratio increased from controls to LVDD to HFpEF (0.43 [0.33-0.56] vs. 0.48 [0.38-0.66] vs. 0.68 [0.55-0.88], p < 0.001). Patents with IGFB-7/IGF1 ratios above the median demonstrated significantly higher left atrial volume index, E/E' ratio, and NT-proBNP levels (all P ≤ 0.02). CONCLUSION: In conclusion, this hypothesis-generating pilot study suggests the IGFBP-7/IGF-1 axis correlates with diastolic function and may serve as a novel biomarker in patients with HFpEF. A rise in IGFBP-7 or the IGFBP-7/IGF-1 ratio may reflect worsening diastolic function, adverse cardiac remodeling, and metabolic derangement.

Duke Scholars

Published In

BMC Cardiovasc Disord

DOI

EISSN

1471-2261

Publication Date

October 21, 2016

Volume

16

Issue

1

Start / End Page

199

Location

England

Related Subject Headings

  • Ventricular Function, Left
  • Time Factors
  • Stroke Volume
  • Prognosis
  • Pilot Projects
  • Middle Aged
  • Male
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor Binding Proteins
  • Humans
 

Citation

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Barroso, M. C., Kramer, F., Greene, S. J., Scheyer, D., Köhler, T., Karoff, M., … Dinh, W. (2016). Serum insulin-like growth factor-1 and its binding protein-7: potential novel biomarkers for heart failure with preserved ejection fraction. BMC Cardiovasc Disord, 16(1), 199. https://doi.org/10.1186/s12872-016-0376-2
Barroso, Michael Coll, Frank Kramer, Stephen J. Greene, Daniel Scheyer, Till Köhler, Martin Karoff, Melchior Seyfarth, Mihai Gheorghiade, and Wilfried Dinh. “Serum insulin-like growth factor-1 and its binding protein-7: potential novel biomarkers for heart failure with preserved ejection fraction.BMC Cardiovasc Disord 16, no. 1 (October 21, 2016): 199. https://doi.org/10.1186/s12872-016-0376-2.
Barroso MC, Kramer F, Greene SJ, Scheyer D, Köhler T, Karoff M, et al. Serum insulin-like growth factor-1 and its binding protein-7: potential novel biomarkers for heart failure with preserved ejection fraction. BMC Cardiovasc Disord. 2016 Oct 21;16(1):199.
Barroso, Michael Coll, et al. “Serum insulin-like growth factor-1 and its binding protein-7: potential novel biomarkers for heart failure with preserved ejection fraction.BMC Cardiovasc Disord, vol. 16, no. 1, Oct. 2016, p. 199. Pubmed, doi:10.1186/s12872-016-0376-2.
Barroso MC, Kramer F, Greene SJ, Scheyer D, Köhler T, Karoff M, Seyfarth M, Gheorghiade M, Dinh W. Serum insulin-like growth factor-1 and its binding protein-7: potential novel biomarkers for heart failure with preserved ejection fraction. BMC Cardiovasc Disord. 2016 Oct 21;16(1):199.
Journal cover image

Published In

BMC Cardiovasc Disord

DOI

EISSN

1471-2261

Publication Date

October 21, 2016

Volume

16

Issue

1

Start / End Page

199

Location

England

Related Subject Headings

  • Ventricular Function, Left
  • Time Factors
  • Stroke Volume
  • Prognosis
  • Pilot Projects
  • Middle Aged
  • Male
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor Binding Proteins
  • Humans