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Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection.

Publication ,  Journal Article
Ray, S; Chiba, N; Yao, C; Guan, X; McConnell, AM; Brockway, B; Que, L; McQualter, JL; Stripp, BR
Published in: Stem Cell Reports
November 8, 2016

Recent studies have implicated keratin 5 (KRT5)+ cells in repopulation of damaged lung tissue following severe H1N1 influenza virus infection. However, the origins of the cells repopulating the injured alveolar region remain controversial. We sought to determine the cellular dynamics of lung repair following influenza infection and define whether nascent KRT5+ cells repopulating alveolar epithelium were derived from pre-existing alveolar or airway progenitor cells. We found that the wound-healing response begins with proliferation of SOX2+ SCGB1A1- KRT5- progenitor cells in airways. These cells generate nascent KRT5+ cells as an early response to airway injury and yield progeny that colonize damaged alveolar parenchyma. Moreover, we show that local alveolar progenitors do not contribute to nascent KRT5+ cells after injury. Repopulation of injured airway and alveolar regions leads to proximalization of distal airways by pseudostratified epithelium and of alveoli by airway-derived epithelial cells that lack the normal characteristics of mature airway or alveolar epithelium.

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Published In

Stem Cell Reports

DOI

EISSN

2213-6711

Publication Date

November 8, 2016

Volume

7

Issue

5

Start / End Page

817 / 825

Location

United States

Related Subject Headings

  • Stem Cells
  • SOXB1 Transcription Factors
  • Respiratory Mucosa
  • Orthomyxoviridae Infections
  • Models, Biological
  • Mice, Transgenic
  • Mice
  • Keratin-5
  • Influenza A Virus, H1N1 Subtype
  • Cell Self Renewal
 

Citation

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Ray, S., Chiba, N., Yao, C., Guan, X., McConnell, A. M., Brockway, B., … Stripp, B. R. (2016). Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection. Stem Cell Reports, 7(5), 817–825. https://doi.org/10.1016/j.stemcr.2016.09.010
Ray, Samriddha, Norika Chiba, Changfu Yao, Xiangrong Guan, Alicia M. McConnell, Brian Brockway, Loretta Que, Jonathan L. McQualter, and Barry R. Stripp. “Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection.Stem Cell Reports 7, no. 5 (November 8, 2016): 817–25. https://doi.org/10.1016/j.stemcr.2016.09.010.
Ray S, Chiba N, Yao C, Guan X, McConnell AM, Brockway B, et al. Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection. Stem Cell Reports. 2016 Nov 8;7(5):817–25.
Ray, Samriddha, et al. “Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection.Stem Cell Reports, vol. 7, no. 5, Nov. 2016, pp. 817–25. Pubmed, doi:10.1016/j.stemcr.2016.09.010.
Ray S, Chiba N, Yao C, Guan X, McConnell AM, Brockway B, Que L, McQualter JL, Stripp BR. Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection. Stem Cell Reports. 2016 Nov 8;7(5):817–825.
Journal cover image

Published In

Stem Cell Reports

DOI

EISSN

2213-6711

Publication Date

November 8, 2016

Volume

7

Issue

5

Start / End Page

817 / 825

Location

United States

Related Subject Headings

  • Stem Cells
  • SOXB1 Transcription Factors
  • Respiratory Mucosa
  • Orthomyxoviridae Infections
  • Models, Biological
  • Mice, Transgenic
  • Mice
  • Keratin-5
  • Influenza A Virus, H1N1 Subtype
  • Cell Self Renewal