Skip to main content
Journal cover image

Comparison of the use and results of sentinel lymph node biopsy in children and young adults with melanoma.

Publication ,  Journal Article
Mu, E; Lange, JR; Strouse, JJ
Published in: Cancer
May 15, 2012

BACKGROUND: Data on sentinel lymph node (SLN) biopsy in children with melanoma are limited. In this study, the authors compared the factors associated with SLN biopsy use and metastases in pediatric and young adult patients with melanoma. METHODS: The 2008 Surveillance, Epidemiology, and End Results (SEER) databases were used to examine melanoma cases from 2003 to 2008. Data extracted include age, sex, race, stage, tumor thickness, ulceration, lymph node status, surgical treatment, and survival. Logistic regression models were used for adjusted analyses. RESULTS: In total, 717 children (age <20 years) and 1368 young adults (age 20-24 years) were identified who were diagnosed with melanoma. Factors that were associated with SLN biopsy use included tumor ulceration (odds ratio [OR], 2.4; 95% confidence interval [CI], 1.4-4.3) and greater thickness (OR, 17; 95% CI, 12-24 for >1 mm vs ≤1 mm), but not younger age (OR, 1.3; 95% CI, 0.94-1.8) in adjusted analyses. SLN metastasis was correlated with ulceration (OR, 3.0; 95% CI, 1.6-5.8), increased thickness (OR, 6.8; 95% CI, 3.1-15 for 2.01-4.0 mm vs ≤1 mm), and for the interaction between age <20 years and thickness 1.01 to 2.00 mm (OR, 6.5; 95% CI, 1.7-25) in adjusted analyses. Children with nonulcerated melanomas that measured 1.01 to 2.00 mm in thickness were significantly more likely to have SLN metastases than young adults (24% vs 4%; P < .001). CONCLUSIONS: Thickness and ulceration were strong predictors of both the use of SLN biopsy and positive SLN biopsy results in children and young adults with melanoma. Compared with young adults, children were more likely to have SLN metastases despite having similar rates of SLN biopsy use.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

May 15, 2012

Volume

118

Issue

10

Start / End Page

2700 / 2707

Location

United States

Related Subject Headings

  • Young Adult
  • Sentinel Lymph Node Biopsy
  • SEER Program
  • Oncology & Carcinogenesis
  • Melanoma
  • Male
  • Lymphatic Metastasis
  • Lymph Node Excision
  • Logistic Models
  • Infant, Newborn
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mu, E., Lange, J. R., & Strouse, J. J. (2012). Comparison of the use and results of sentinel lymph node biopsy in children and young adults with melanoma. Cancer, 118(10), 2700–2707. https://doi.org/10.1002/cncr.26578
Mu, Euphemia, Julie R. Lange, and John J. Strouse. “Comparison of the use and results of sentinel lymph node biopsy in children and young adults with melanoma.Cancer 118, no. 10 (May 15, 2012): 2700–2707. https://doi.org/10.1002/cncr.26578.
Mu, Euphemia, et al. “Comparison of the use and results of sentinel lymph node biopsy in children and young adults with melanoma.Cancer, vol. 118, no. 10, May 2012, pp. 2700–07. Pubmed, doi:10.1002/cncr.26578.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

May 15, 2012

Volume

118

Issue

10

Start / End Page

2700 / 2707

Location

United States

Related Subject Headings

  • Young Adult
  • Sentinel Lymph Node Biopsy
  • SEER Program
  • Oncology & Carcinogenesis
  • Melanoma
  • Male
  • Lymphatic Metastasis
  • Lymph Node Excision
  • Logistic Models
  • Infant, Newborn