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Parent education and biologic factors influence on cognition in sickle cell anemia.

Publication ,  Journal Article
King, AA; Strouse, JJ; Rodeghier, MJ; Compas, BE; Casella, JF; McKinstry, RC; Noetzel, MJ; Quinn, CT; Ichord, R; Dowling, MM; Miller, JP; Debaun, MR
Published in: Am J Hematol
February 2014

Children with sickle cell anemia have a high prevalence of silent cerebral infarcts (SCIs) that are associated with decreased full-scale intelligence quotient (FSIQ). While the educational attainment of parents is a known strong predictor of the cognitive development of children in general, the role of parental education in sickle cell anemia along with other factors that adversely affect cognitive function (anemia, cerebral infarcts) is not known. We tested the hypothesis that both the presence of SCI and parental education would impact FSIQ in children with sickle cell anemia. A multicenter, cross-sectional study was conducted in 19 US sites of the Silent Infarct Transfusion Trial among children with sickle cell anemia, age 5-15 years. All were screened for SCIs. Participants with and without SCI were administered the Wechsler Abbreviated Scale of Intelligence. A total of 150 participants (107 with and 43 without SCIs) were included in the analysis. In a multivariable linear regression model for FSIQ, the absence of college education for the head of household was associated with a decrease of 6.2 points (P = 0.005); presence of SCI with a 5.2 point decrease (P = 0.017); each $1000 of family income per capita with a 0.33 point increase (P = 0.023); each increase of 1 year in age with a 0.96 point decrease (P = 0.023); and each 1% (absolute) decrease in hemoglobin oxygen saturation with 0.75 point decrease (P = 0.030). In conclusion, FSIQ in children with sickle cell anemia is best accounted for by a multivariate model that includes both biologic and socioenvironmental factors.

Duke Scholars

Published In

Am J Hematol

DOI

EISSN

1096-8652

Publication Date

February 2014

Volume

89

Issue

2

Start / End Page

162 / 167

Location

United States

Related Subject Headings

  • Socioeconomic Factors
  • Risk Factors
  • Prognosis
  • Oxygen Consumption
  • Male
  • Magnetic Resonance Imaging
  • Immunology
  • Humans
  • Hemoglobins
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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King, A. A., Strouse, J. J., Rodeghier, M. J., Compas, B. E., Casella, J. F., McKinstry, R. C., … Debaun, M. R. (2014). Parent education and biologic factors influence on cognition in sickle cell anemia. Am J Hematol, 89(2), 162–167. https://doi.org/10.1002/ajh.23604
King, Allison A., John J. Strouse, Mark J. Rodeghier, Bruce E. Compas, James F. Casella, Robert C. McKinstry, Michael J. Noetzel, et al. “Parent education and biologic factors influence on cognition in sickle cell anemia.Am J Hematol 89, no. 2 (February 2014): 162–67. https://doi.org/10.1002/ajh.23604.
King AA, Strouse JJ, Rodeghier MJ, Compas BE, Casella JF, McKinstry RC, et al. Parent education and biologic factors influence on cognition in sickle cell anemia. Am J Hematol. 2014 Feb;89(2):162–7.
King, Allison A., et al. “Parent education and biologic factors influence on cognition in sickle cell anemia.Am J Hematol, vol. 89, no. 2, Feb. 2014, pp. 162–67. Pubmed, doi:10.1002/ajh.23604.
King AA, Strouse JJ, Rodeghier MJ, Compas BE, Casella JF, McKinstry RC, Noetzel MJ, Quinn CT, Ichord R, Dowling MM, Miller JP, Debaun MR. Parent education and biologic factors influence on cognition in sickle cell anemia. Am J Hematol. 2014 Feb;89(2):162–167.
Journal cover image

Published In

Am J Hematol

DOI

EISSN

1096-8652

Publication Date

February 2014

Volume

89

Issue

2

Start / End Page

162 / 167

Location

United States

Related Subject Headings

  • Socioeconomic Factors
  • Risk Factors
  • Prognosis
  • Oxygen Consumption
  • Male
  • Magnetic Resonance Imaging
  • Immunology
  • Humans
  • Hemoglobins
  • Female