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[Role of omega-3 polyunsaturated fatty acids after acute coronary syndrome].

Publication ,  Journal Article
Temporelli, PL; Buda, S; Greene, SJ
Published in: G Ital Cardiol (Rome)
2016

The role of omega-3 polyunsaturated fatty acids (PUFAs) in the secondary prevention of cardiovascular disease has recently been debated. The GISSI-Prevention trial demonstrated that supplementation with 1 g/day of eicosapentaenoic acid plus docosahexaenoic acid (EPA/DHA) was associated with a reduction in all-cause and cardiovascular mortality in patients with myocardial infarction. However, some subsequent meta-analyses, though not without methodological flaws, did not confirm the beneficial effect on cardiovascular mortality. More evidence has recently become available from the analysis of "real-world" data that point to the effectiveness of PUFA supplementation in reducing cardiovascular events in patients with recent acute coronary syndrome. Meantime, in the determination no. 94 by the Italian Medicines Agency (AIFA), reimbursement of PUFAs containing at least 85% of EPA and DHA has been recognized for 12 months in patients with acute coronary syndrome and ejection fraction >40% and for 18 months in those with ejection fraction ≤40%.

Duke Scholars

Published In

G Ital Cardiol (Rome)

DOI

ISSN

1827-6806

Publication Date

2016

Volume

17

Issue

7 Suppl 1

Start / End Page

3 / 10

Location

Italy

Related Subject Headings

  • Italy
  • Humans
  • Fatty Acids, Unsaturated
  • Fatty Acids, Omega-3
  • Eicosapentaenoic Acid
  • Cardiovascular System & Hematology
  • Acute Coronary Syndrome
 

Citation

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MLA
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Temporelli, P. L., Buda, S., & Greene, S. J. (2016). [Role of omega-3 polyunsaturated fatty acids after acute coronary syndrome]. G Ital Cardiol (Rome), 17(7 Suppl 1), 3–10. https://doi.org/10.1714/2336.25080
Temporelli, Pier Luigi, Stefano Buda, and Stephen J. Greene. “[Role of omega-3 polyunsaturated fatty acids after acute coronary syndrome].G Ital Cardiol (Rome) 17, no. 7 Suppl 1 (2016): 3–10. https://doi.org/10.1714/2336.25080.
Temporelli PL, Buda S, Greene SJ. [Role of omega-3 polyunsaturated fatty acids after acute coronary syndrome]. G Ital Cardiol (Rome). 2016;17(7 Suppl 1):3–10.
Temporelli, Pier Luigi, et al. “[Role of omega-3 polyunsaturated fatty acids after acute coronary syndrome].G Ital Cardiol (Rome), vol. 17, no. 7 Suppl 1, 2016, pp. 3–10. Pubmed, doi:10.1714/2336.25080.
Temporelli PL, Buda S, Greene SJ. [Role of omega-3 polyunsaturated fatty acids after acute coronary syndrome]. G Ital Cardiol (Rome). 2016;17(7 Suppl 1):3–10.

Published In

G Ital Cardiol (Rome)

DOI

ISSN

1827-6806

Publication Date

2016

Volume

17

Issue

7 Suppl 1

Start / End Page

3 / 10

Location

Italy

Related Subject Headings

  • Italy
  • Humans
  • Fatty Acids, Unsaturated
  • Fatty Acids, Omega-3
  • Eicosapentaenoic Acid
  • Cardiovascular System & Hematology
  • Acute Coronary Syndrome