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Is there a difference in bloodstream infections in critically ill patients associated with ready-to-use versus compounded parenteral nutrition?

Publication ,  Journal Article
Pontes-Arruda, A; Zaloga, G; Wischmeyer, P; Turpin, R; Liu, FX; Mercaldi, C
Published in: Clin Nutr
October 2012

BACKGROUND & AIMS: Parenteral nutrition is widely used in critically ill patients receiving nutritional support. Several previous studies associated the use of parenteral nutrition with the development of bloodstream infections. This study compared bloodstream infections in critical care patients receiving parenteral nutrition (PN) prepared via conventional compounding versus premixed multichamber bags. METHODS: Records in the Premier Perspective™ database for all in patients ≥ 18 years of age, with a minimum 3-day intensive care unit stay, who received PN between 2005 and 2007 were analyzed (n = 15,328). Statistical analysis of data, grouped according to preparation method, compared differences in both observed bloodstream infection rates and adjusted rates, using logistic regression to examine the impact of hospital and patient baseline characteristics. RESULTS: Patients receiving compounded parenteral nutrition had longer intensive care unit stays (11.3 vs. 9.1 days) and longer hospital stays (22.6 vs. 19.4 days); both P < .001. After adjusting for baseline differences, the probability for bloodstream infections was 19% higher when using compounded parenteral nutrition vs. multichamber bags (29.6 vs. 24.9%; odd ratio = 1.29; 95% confidence interval = 1.06-1.59). CONCLUSION: In this retrospective review of a large patient database the adjusted probability of bloodstream infection was significantly lower in patients receiving multichamber bags than compounded parenteral nutrition. These findings need to be investigated further in high quality observational studies and prospective clinical trials.

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Published In

Clin Nutr

DOI

EISSN

1532-1983

Publication Date

October 2012

Volume

31

Issue

5

Start / End Page

728 / 734

Location

England

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Retrospective Studies
  • Parenteral Nutrition Solutions
  • Parenteral Nutrition
  • Odds Ratio
  • Nutrition & Dietetics
  • Middle Aged
  • Male
  • Logistic Models
 

Citation

APA
Chicago
ICMJE
MLA
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Pontes-Arruda, A., Zaloga, G., Wischmeyer, P., Turpin, R., Liu, F. X., & Mercaldi, C. (2012). Is there a difference in bloodstream infections in critically ill patients associated with ready-to-use versus compounded parenteral nutrition? Clin Nutr, 31(5), 728–734. https://doi.org/10.1016/j.clnu.2012.03.004
Pontes-Arruda, Alessandro, Gary Zaloga, Paul Wischmeyer, Robin Turpin, Frank X. Liu, and Catherine Mercaldi. “Is there a difference in bloodstream infections in critically ill patients associated with ready-to-use versus compounded parenteral nutrition?Clin Nutr 31, no. 5 (October 2012): 728–34. https://doi.org/10.1016/j.clnu.2012.03.004.
Pontes-Arruda A, Zaloga G, Wischmeyer P, Turpin R, Liu FX, Mercaldi C. Is there a difference in bloodstream infections in critically ill patients associated with ready-to-use versus compounded parenteral nutrition? Clin Nutr. 2012 Oct;31(5):728–34.
Pontes-Arruda, Alessandro, et al. “Is there a difference in bloodstream infections in critically ill patients associated with ready-to-use versus compounded parenteral nutrition?Clin Nutr, vol. 31, no. 5, Oct. 2012, pp. 728–34. Pubmed, doi:10.1016/j.clnu.2012.03.004.
Pontes-Arruda A, Zaloga G, Wischmeyer P, Turpin R, Liu FX, Mercaldi C. Is there a difference in bloodstream infections in critically ill patients associated with ready-to-use versus compounded parenteral nutrition? Clin Nutr. 2012 Oct;31(5):728–734.
Journal cover image

Published In

Clin Nutr

DOI

EISSN

1532-1983

Publication Date

October 2012

Volume

31

Issue

5

Start / End Page

728 / 734

Location

England

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Retrospective Studies
  • Parenteral Nutrition Solutions
  • Parenteral Nutrition
  • Odds Ratio
  • Nutrition & Dietetics
  • Middle Aged
  • Male
  • Logistic Models