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Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus.

Publication ,  Journal Article
Yang, Q; Chen, Y; Fu, C; Chang, M; Peng, Y; Wang, R
Published in: Protein Pept Lett
2006

Electric field stimulation (EFS) causes excitatory non adrenergic-non cholinergic (eNANC) and cholinergic constrictions in the guinea pig isolated bronchus, the activation of eNANC and cholinergic nerves respectively. We investigated the effects of [Nphe1]nociceptin(1-13)NH2 ([Nphe1]NC(1-13)NH2), [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2 ([F/G] NC(1-13)NH2), and nocistatin (NST) on nociceptin (NC) inhibited constrictions in isolated bronchus of guinea pig. The results show that NC (1 micromol/L) inhibited EFS-induced eNANC and cholinergic constrictions compared with the control, in which nociceptin was not applied. After pretreatment with [Nphe1]NC(1-13)NH2, [F/G]NC(1-13)NH2, or NST, the inhibitions of NC were antagonized by [Nphe1]NC(1-13)NH2 and [F/G]NC(1-13)NH2 but not NST. However, [Nphe1]NC(1-13)NH2, [F/G]NC(1-13)NH2, and NST did not affect the inhibitions induced by morphine. Furthermore, [Nphe1]NC(1-13)NH2, [F/G]NC(1-13)NH2 and NST did not cause any appreciable effects on EFS-induced eNANC and cholinergic constrictions in guinea pig bronchi. The results demonstrate that [Nphe1]NC(1-13)NH2 and [F/G]NC(1- 13)NH2 but not NST act as selective antagonists of the NC receptor and the effects of NC on EFS-induced constrictions of guinea pig isolated bronchus.

Duke Scholars

Published In

Protein Pept Lett

DOI

ISSN

0929-8665

Publication Date

2006

Volume

13

Issue

2

Start / End Page

185 / 188

Location

Netherlands

Related Subject Headings

  • Peptide Fragments
  • Opioid Peptides
  • Nociceptin
  • Morphine
  • Male
  • Guinea Pigs
  • Female
  • Electric Stimulation
  • Bronchi
  • Biophysics
 

Citation

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ICMJE
MLA
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Yang, Q., Chen, Y., Fu, C., Chang, M., Peng, Y., & Wang, R. (2006). Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus. Protein Pept Lett, 13(2), 185–188. https://doi.org/10.2174/092986606775101706
Yang, Qi, Yong Chen, Caiyun Fu, Min Chang, Yali Peng, and Rui Wang. “Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus.Protein Pept Lett 13, no. 2 (2006): 185–88. https://doi.org/10.2174/092986606775101706.
Yang, Qi, et al. “Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus.Protein Pept Lett, vol. 13, no. 2, 2006, pp. 185–88. Pubmed, doi:10.2174/092986606775101706.
Journal cover image

Published In

Protein Pept Lett

DOI

ISSN

0929-8665

Publication Date

2006

Volume

13

Issue

2

Start / End Page

185 / 188

Location

Netherlands

Related Subject Headings

  • Peptide Fragments
  • Opioid Peptides
  • Nociceptin
  • Morphine
  • Male
  • Guinea Pigs
  • Female
  • Electric Stimulation
  • Bronchi
  • Biophysics