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A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality.

Publication ,  Journal Article
McGarrah, RW; Kelly, JP; Craig, DM; Haynes, C; Jessee, RC; Huffman, KM; Kraus, WE; Shah, SH
Published in: Clin Chem
January 2017

BACKGROUND: Evidence suggests that systemic inflammation may adversely impact HDL function. In this study we sought to evaluate the independent and incremental predictive performance of GlycA-a novel serum inflammatory biomarker that is an aggregate measure of enzymatically glycosylated acute phase proteins-and HDL subclasses on adverse events in a retrospective observational study of a secondary prevention population and to understand a priori defined potential interactions between GlycA and HDL subclasses. METHODS: GlycA and HDL subclasses were measured using proton nuclear magnetic resonance spectroscopy in 7617 individuals in the CATHGEN (CATHeterization GENetics) cardiac catheterization biorepository. RESULTS: GlycA was associated with presence [odds ratio (OR) 1.07 (1.02-1.13), P = 0.01] and extent [OR 1.08 (1.03, 1.12) P < 0.0005] of coronary artery disease and with all-cause mortality [hazard ratio (HR) 1.34 (1.29-1.39), P < 0.0001], cardiovascular mortality [1.37 (1.30-1.45), P < 0.0001] and noncardiovascular mortality [1.46 (1.39-1.54) P < 0.0001] in models adjusted for 10 cardiovascular risk factors. GlycA and smaller HDL subclasses had independent but opposite effects on mortality risk prediction, with smaller HDL subclasses being protective [HR 0.69 (0.66-0.72), P < 0.0001]. There was an interaction between GlycA and smaller HDL subclasses-increasing GlycA concentrations attenuated the inverse association of smaller HDL subclasses with mortality. Adding GlycA and smaller HDL subclasses into the GRACE (Global Registry of Acute Coronary Events) and Framingham Heart Study Risk Scores improved mortality risk prediction, discrimination and reclassification. CONCLUSIONS: These findings highlight the interaction of systemic inflammation and HDL with clinical outcomes and may increase precision for clinical risk assessment in secondary prevention populations.

Duke Scholars

Published In

Clin Chem

DOI

EISSN

1530-8561

Publication Date

January 2017

Volume

63

Issue

1

Start / End Page

288 / 296

Location

England

Related Subject Headings

  • Survival Rate
  • Polysaccharides
  • Nuclear Magnetic Resonance, Biomolecular
  • Middle Aged
  • Male
  • Lipoproteins
  • Inflammation
  • Humans
  • General Clinical Medicine
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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McGarrah, R. W., Kelly, J. P., Craig, D. M., Haynes, C., Jessee, R. C., Huffman, K. M., … Shah, S. H. (2017). A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality. Clin Chem, 63(1), 288–296. https://doi.org/10.1373/clinchem.2016.261636
McGarrah, Robert W., Jacob P. Kelly, Damian M. Craig, Carol Haynes, Ryan C. Jessee, Kim M. Huffman, William E. Kraus, and Svati H. Shah. “A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality.Clin Chem 63, no. 1 (January 2017): 288–96. https://doi.org/10.1373/clinchem.2016.261636.
McGarrah RW, Kelly JP, Craig DM, Haynes C, Jessee RC, Huffman KM, et al. A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality. Clin Chem. 2017 Jan;63(1):288–96.
McGarrah, Robert W., et al. “A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality.Clin Chem, vol. 63, no. 1, Jan. 2017, pp. 288–96. Pubmed, doi:10.1373/clinchem.2016.261636.
McGarrah RW, Kelly JP, Craig DM, Haynes C, Jessee RC, Huffman KM, Kraus WE, Shah SH. A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality. Clin Chem. 2017 Jan;63(1):288–296.

Published In

Clin Chem

DOI

EISSN

1530-8561

Publication Date

January 2017

Volume

63

Issue

1

Start / End Page

288 / 296

Location

England

Related Subject Headings

  • Survival Rate
  • Polysaccharides
  • Nuclear Magnetic Resonance, Biomolecular
  • Middle Aged
  • Male
  • Lipoproteins
  • Inflammation
  • Humans
  • General Clinical Medicine
  • Female