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Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism.

Publication ,  Journal Article
Greer, RL; Dong, X; Moraes, ACF; Zielke, RA; Fernandes, GR; Peremyslova, E; Vasquez-Perez, S; Schoenborn, AA; Gomes, EP; Pereira, AC; Yao, M ...
Published in: Nat Commun
November 14, 2016

Cross-talk between the gut microbiota and the host immune system regulates host metabolism, and its dysregulation can cause metabolic disease. Here, we show that the gut microbe Akkermansia muciniphila can mediate negative effects of IFNγ on glucose tolerance. In IFNγ-deficient mice, A. muciniphila is significantly increased and restoration of IFNγ levels reduces A. muciniphila abundance. We further show that IFNγ-knockout mice whose microbiota does not contain A. muciniphila do not show improvement in glucose tolerance and adding back A. muciniphila promoted enhanced glucose tolerance. We go on to identify Irgm1 as an IFNγ-regulated gene in the mouse ileum that controls gut A. muciniphila levels. A. muciniphila is also linked to IFNγ-regulated gene expression in the intestine and glucose parameters in humans, suggesting that this trialogue between IFNγ, A. muciniphila and glucose tolerance might be an evolutionally conserved mechanism regulating metabolic health in mice and humans.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

November 14, 2016

Volume

7

Start / End Page

13329

Location

England

Related Subject Headings

  • Verrucomicrobia
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Interferon-gamma
  • Ileum
  • Humans
  • Glucose
  • Gene Expression
  • Gastrointestinal Microbiome
  • GTP-Binding Proteins
 

Citation

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MLA
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Greer, R. L., Dong, X., Moraes, A. C. F., Zielke, R. A., Fernandes, G. R., Peremyslova, E., … Shulzhenko, N. (2016). Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism. Nat Commun, 7, 13329. https://doi.org/10.1038/ncomms13329
Greer, Renee L., Xiaoxi Dong, Ana Carolina F. Moraes, Ryszard A. Zielke, Gabriel R. Fernandes, Ekaterina Peremyslova, Stephany Vasquez-Perez, et al. “Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism.Nat Commun 7 (November 14, 2016): 13329. https://doi.org/10.1038/ncomms13329.
Greer RL, Dong X, Moraes ACF, Zielke RA, Fernandes GR, Peremyslova E, et al. Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism. Nat Commun. 2016 Nov 14;7:13329.
Greer, Renee L., et al. “Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism.Nat Commun, vol. 7, Nov. 2016, p. 13329. Pubmed, doi:10.1038/ncomms13329.
Greer RL, Dong X, Moraes ACF, Zielke RA, Fernandes GR, Peremyslova E, Vasquez-Perez S, Schoenborn AA, Gomes EP, Pereira AC, Ferreira SRG, Yao M, Fuss IJ, Strober W, Sikora AE, Taylor GA, Gulati AS, Morgun A, Shulzhenko N. Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism. Nat Commun. 2016 Nov 14;7:13329.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

November 14, 2016

Volume

7

Start / End Page

13329

Location

England

Related Subject Headings

  • Verrucomicrobia
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Interferon-gamma
  • Ileum
  • Humans
  • Glucose
  • Gene Expression
  • Gastrointestinal Microbiome
  • GTP-Binding Proteins