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Long-term effects of a high-carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance.

Publication ,  Journal Article
Hughes, VA; Fiatarone, MA; Fielding, RA; Ferrara, CM; Elahi, D; Evans, WJ
Published in: Am J Clin Nutr
August 1995

Carbohydrate metabolism was assessed in 20 glucose-intolerant subjects before and after 12 wk on a high-carbohydrate diet (HC) or the diet combined with exercise training (HC-EX). The diet provided 60% of energy as carbohydrate and 20% as fat. Neither treatment altered fasting glucose or insulin concentrations or their response to a meal. During a glucose clamp (216 pmol insulin/L) glucose disposal increased from 13.2 +/- 0.83 to 14.6 +/- 0.83 mumol.kg fat-free mass-1.min-1 (P < 0.05) in both groups. During more pronounced hyperinsulinemia (654 pmol/L) glucose disposal did not change significantly (49.9 +/- 3.8 to 50.7 +/- 3.8 mumol.kg fat-free mass-1.min-1). Muscle glycogen increased in the HC-EX group (78.5 +/- 8.1 to 161.1 +/- 15.7 mmol glucose/kg muscle), with no changes in the HC group. These results do not support the recommendation to increase the dietary carbohydrate content for improving postprandial glucose metabolism or insulin action in glucose-intolerant adults unless combined with exercise training, which promotes muscle glycogen storage.

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Published In

Am J Clin Nutr

DOI

ISSN

0002-9165

Publication Date

August 1995

Volume

62

Issue

2

Start / End Page

426 / 433

Location

United States

Related Subject Headings

  • Time Factors
  • Nutrition & Dietetics
  • Muscle, Skeletal
  • Middle Aged
  • Male
  • Insulin Resistance
  • Insulin
  • Hyperinsulinism
  • Humans
  • Glycogen
 

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Hughes, V. A., Fiatarone, M. A., Fielding, R. A., Ferrara, C. M., Elahi, D., & Evans, W. J. (1995). Long-term effects of a high-carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance. Am J Clin Nutr, 62(2), 426–433. https://doi.org/10.1093/ajcn/62.2.426
Hughes, V. A., M. A. Fiatarone, R. A. Fielding, C. M. Ferrara, D. Elahi, and W. J. Evans. “Long-term effects of a high-carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance.Am J Clin Nutr 62, no. 2 (August 1995): 426–33. https://doi.org/10.1093/ajcn/62.2.426.
Hughes VA, Fiatarone MA, Fielding RA, Ferrara CM, Elahi D, Evans WJ. Long-term effects of a high-carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance. Am J Clin Nutr. 1995 Aug;62(2):426–33.
Hughes, V. A., et al. “Long-term effects of a high-carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance.Am J Clin Nutr, vol. 62, no. 2, Aug. 1995, pp. 426–33. Pubmed, doi:10.1093/ajcn/62.2.426.
Hughes VA, Fiatarone MA, Fielding RA, Ferrara CM, Elahi D, Evans WJ. Long-term effects of a high-carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance. Am J Clin Nutr. 1995 Aug;62(2):426–433.

Published In

Am J Clin Nutr

DOI

ISSN

0002-9165

Publication Date

August 1995

Volume

62

Issue

2

Start / End Page

426 / 433

Location

United States

Related Subject Headings

  • Time Factors
  • Nutrition & Dietetics
  • Muscle, Skeletal
  • Middle Aged
  • Male
  • Insulin Resistance
  • Insulin
  • Hyperinsulinism
  • Humans
  • Glycogen