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Eccentric exercise-induced muscle damage impairs muscle glycogen repletion.

Publication ,  Journal Article
O'Reilly, KP; Warhol, MJ; Fielding, RA; Frontera, WR; Meredith, CN; Evans, WJ
Published in: J Appl Physiol (1985)
July 1987

Five healthy untrained young male subjects were studied before, immediately after, and 10 days after a 45-min bout of eccentric exercise on a cycle ergometer (201 W). The subjects were sedentary at all other times and consumed a eucaloric meat-free diet. Needle biopsies of the vastus lateralis muscle were examined for intracellular damage and glycogen content. Immediately after exercise, muscle samples showed myofibrillar tearing and edema. At 10 days, there was myofibrillar necrosis, inflammatory cell infiltration, and no evidence of myofibrillar regeneration. Glycogen utilization during the exercise bout was 33 mmol glycosyl units/kg muscle, consistent with the metabolic intensity of 44% of maximal O2 uptake; however, the significant glycogen use by type II fibers contrasted with concentric exercise performed at this intensity. At 10 days after exercise, muscle glycogen was still depleted, in both type I and II fibers. It is possible that the alterations in muscle ultrastructures were related to the lack of repletion of muscle glycogen. Damage produced by eccentric exercise was more persistent than previously reported, indicating that more than 10 days may be necessary for recovery of muscle ultrastructure and carbohydrate reserves.

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Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

July 1987

Volume

63

Issue

1

Start / End Page

252 / 256

Location

United States

Related Subject Headings

  • Time Factors
  • Physiology
  • Physical Exertion
  • Muscles
  • Microscopy, Electron
  • Male
  • Kinetics
  • Humans
  • Glycogen
  • Biopsy
 

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O’Reilly, K. P., Warhol, M. J., Fielding, R. A., Frontera, W. R., Meredith, C. N., & Evans, W. J. (1987). Eccentric exercise-induced muscle damage impairs muscle glycogen repletion. J Appl Physiol (1985), 63(1), 252–256. https://doi.org/10.1152/jappl.1987.63.1.252
O’Reilly, K. P., M. J. Warhol, R. A. Fielding, W. R. Frontera, C. N. Meredith, and W. J. Evans. “Eccentric exercise-induced muscle damage impairs muscle glycogen repletion.J Appl Physiol (1985) 63, no. 1 (July 1987): 252–56. https://doi.org/10.1152/jappl.1987.63.1.252.
O’Reilly KP, Warhol MJ, Fielding RA, Frontera WR, Meredith CN, Evans WJ. Eccentric exercise-induced muscle damage impairs muscle glycogen repletion. J Appl Physiol (1985). 1987 Jul;63(1):252–6.
O’Reilly, K. P., et al. “Eccentric exercise-induced muscle damage impairs muscle glycogen repletion.J Appl Physiol (1985), vol. 63, no. 1, July 1987, pp. 252–56. Pubmed, doi:10.1152/jappl.1987.63.1.252.
O’Reilly KP, Warhol MJ, Fielding RA, Frontera WR, Meredith CN, Evans WJ. Eccentric exercise-induced muscle damage impairs muscle glycogen repletion. J Appl Physiol (1985). 1987 Jul;63(1):252–256.

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

July 1987

Volume

63

Issue

1

Start / End Page

252 / 256

Location

United States

Related Subject Headings

  • Time Factors
  • Physiology
  • Physical Exertion
  • Muscles
  • Microscopy, Electron
  • Male
  • Kinetics
  • Humans
  • Glycogen
  • Biopsy