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Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults.

Publication ,  Journal Article
Coker, RH; Hays, NP; Williams, RH; Xu, L; Wolfe, RR; Evans, WJ
Published in: J Gerontol A Biol Sci Med Sci
March 2014

BACKGROUND: The effects of bed rest on the dysregulation of fatty acid and glucose metabolism have not been addressed in the older population. OBJECTIVE: We examined the effect of 10 days of bed rest on fatty acid kinetics and hepatic and peripheral insulin resistance in aging. METHODS: We utilized an octreotide, basal glucagon replacement, multistage insulin infusion, and the concomitant infusion of [6,6 (2)H₂]glucose to derive insulin-mediated suppression of glucose production and insulin-stimulated glucose disposal in nine older, overweight individuals (body mass index 28.1 ± 1.7 kg m(-2); 39.9% ± 1.9% fat). During the multistage insulin infusion, we also infused [1-(13)C]palmitate to examine free fatty acid rate of appearance (R(a)). RESULTS: Body weight, % body fat, and energy metabolism did not change with bed rest. There was a significant decrease (-2291 ± 316 cm(3)) in visceral fat, and no change in abdominal subcutaneous fat with bed rest. Insulin-mediated suppression of glucose production was modest prior to bed rest and was further reduced (>15% ± 2%) by bed rest. There was also a minor decrease in the insulin-mediated suppression of free fatty acid R(a) after bed rest and, as a consequence, a small variation in plasma free fatty acid from pre- to post-bed rest in the first stage of the multistage insulin infusion. There was also a significant bed rest-induced decline (>2.0 ± 0.6 mg kg FFM(-1) min(-1)) in insulin-stimulated glucose disposal. CONCLUSIONS: Preexisting impairments in insulin sensitivity are worsened by bed rest and seem linked to alterations in the regulation of free fatty acid in older, overweight individuals.

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Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

March 2014

Volume

69

Issue

3

Start / End Page

363 / 370

Location

United States

Related Subject Headings

  • Triglycerides
  • Subcutaneous Fat, Abdominal
  • Palmitates
  • Oxygen Consumption
  • Overweight
  • Octreotide
  • Middle Aged
  • Male
  • Liver
  • Intra-Abdominal Fat
 

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Coker, R. H., Hays, N. P., Williams, R. H., Xu, L., Wolfe, R. R., & Evans, W. J. (2014). Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults. J Gerontol A Biol Sci Med Sci, 69(3), 363–370. https://doi.org/10.1093/gerona/glt100
Coker, Robert H., Nicholas P. Hays, Rick H. Williams, Lulu Xu, Robert R. Wolfe, and William J. Evans. “Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults.J Gerontol A Biol Sci Med Sci 69, no. 3 (March 2014): 363–70. https://doi.org/10.1093/gerona/glt100.
Coker RH, Hays NP, Williams RH, Xu L, Wolfe RR, Evans WJ. Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults. J Gerontol A Biol Sci Med Sci. 2014 Mar;69(3):363–70.
Coker, Robert H., et al. “Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults.J Gerontol A Biol Sci Med Sci, vol. 69, no. 3, Mar. 2014, pp. 363–70. Pubmed, doi:10.1093/gerona/glt100.
Coker RH, Hays NP, Williams RH, Xu L, Wolfe RR, Evans WJ. Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults. J Gerontol A Biol Sci Med Sci. 2014 Mar;69(3):363–370.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

March 2014

Volume

69

Issue

3

Start / End Page

363 / 370

Location

United States

Related Subject Headings

  • Triglycerides
  • Subcutaneous Fat, Abdominal
  • Palmitates
  • Oxygen Consumption
  • Overweight
  • Octreotide
  • Middle Aged
  • Male
  • Liver
  • Intra-Abdominal Fat