Skip to main content
Journal cover image

Social status alters immune regulation and response to infection in macaques.

Publication ,  Journal Article
Snyder-Mackler, N; Sanz, J; Kohn, JN; Brinkworth, JF; Morrow, S; Shaver, AO; Grenier, J-C; Pique-Regi, R; Johnson, ZP; Wilson, ME; Barreiro, LB ...
Published in: Science (New York, N.Y.)
November 2016

Social status is one of the strongest predictors of human disease risk and mortality, and it also influences Darwinian fitness in social mammals more generally. To understand the biological basis of these effects, we combined genomics with a social status manipulation in female rhesus macaques to investigate how status alters immune function. We demonstrate causal but largely plastic social status effects on immune cell proportions, cell type-specific gene expression levels, and the gene expression response to immune challenge. Further, we identify specific transcription factor signaling pathways that explain these differences, including low-status-associated polarization of the Toll-like receptor 4 signaling pathway toward a proinflammatory response. Our findings provide insight into the direct biological effects of social inequality on immune function, thus improving our understanding of social gradients in health.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

November 2016

Volume

354

Issue

6315

Start / End Page

1041 / 1045

Related Subject Headings

  • Toll-Like Receptor 4
  • Social Class
  • Signal Transduction
  • Macaca mulatta
  • Lipopolysaccharides
  • Leukocytes
  • Leukocyte Count
  • Immunity, Innate
  • Immunity, Cellular
  • Immune System
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Snyder-Mackler, N., Sanz, J., Kohn, J. N., Brinkworth, J. F., Morrow, S., Shaver, A. O., … Tung, J. (2016). Social status alters immune regulation and response to infection in macaques. Science (New York, N.Y.), 354(6315), 1041–1045. https://doi.org/10.1126/science.aah3580
Snyder-Mackler, Noah, Joaquín Sanz, Jordan N. Kohn, Jessica F. Brinkworth, Shauna Morrow, Amanda O. Shaver, Jean-Christophe Grenier, et al. “Social status alters immune regulation and response to infection in macaques.Science (New York, N.Y.) 354, no. 6315 (November 2016): 1041–45. https://doi.org/10.1126/science.aah3580.
Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, et al. Social status alters immune regulation and response to infection in macaques. Science (New York, NY). 2016 Nov;354(6315):1041–5.
Snyder-Mackler, Noah, et al. “Social status alters immune regulation and response to infection in macaques.Science (New York, N.Y.), vol. 354, no. 6315, Nov. 2016, pp. 1041–45. Epmc, doi:10.1126/science.aah3580.
Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, Grenier J-C, Pique-Regi R, Johnson ZP, Wilson ME, Barreiro LB, Tung J. Social status alters immune regulation and response to infection in macaques. Science (New York, NY). 2016 Nov;354(6315):1041–1045.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

November 2016

Volume

354

Issue

6315

Start / End Page

1041 / 1045

Related Subject Headings

  • Toll-Like Receptor 4
  • Social Class
  • Signal Transduction
  • Macaca mulatta
  • Lipopolysaccharides
  • Leukocytes
  • Leukocyte Count
  • Immunity, Innate
  • Immunity, Cellular
  • Immune System