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Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.

Publication ,  Journal Article
Deng, W; Yang, J; Lin, X; Shin, J; Gao, J; Zhong, X-P
Published in: J Immunol
January 1, 2017

Alveolar macrophages (AMϕ) have the capacity of local self-renewal through adult life; however, mechanisms that regulate AMϕ self-renewal remain poorly understood. We found that myeloid-specific deletion of Raptor, an essential component of the mammalian/mechanistic target of rapamycin complex (mTORC)1, resulted in a marked decrease of this population of cells accompanying altered phenotypic features and impaired phagocytosis activity. We demonstrated further that Raptor/mTORC1 deficiency did not affect AMϕ development, but compromised its proliferative activity at cell cycle entry in the steady-state as well as in the context of repopulation in irradiation chimeras. Mechanically, mTORC1 confers AMϕ optimal responsiveness to GM-CSF-induced proliferation. Thus, our results demonstrate an essential role of mTORC1 for AMϕ homeostasis by regulating proliferative renewal.

Duke Scholars

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

January 1, 2017

Volume

198

Issue

1

Start / End Page

492 / 504

Location

United States

Related Subject Headings

  • TOR Serine-Threonine Kinases
  • Real-Time Polymerase Chain Reaction
  • Multiprotein Complexes
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Mechanistic Target of Rapamycin Complex 1
  • Macrophages, Alveolar
  • Immunology
  • Homeostasis
 

Citation

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MLA
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Deng, W., Yang, J., Lin, X., Shin, J., Gao, J., & Zhong, X.-P. (2017). Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages. J Immunol, 198(1), 492–504. https://doi.org/10.4049/jimmunol.1501845
Deng, Wenhai, Jialong Yang, Xingguang Lin, Jinwook Shin, Jimin Gao, and Xiao-Ping Zhong. “Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.J Immunol 198, no. 1 (January 1, 2017): 492–504. https://doi.org/10.4049/jimmunol.1501845.
Deng W, Yang J, Lin X, Shin J, Gao J, Zhong X-P. Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages. J Immunol. 2017 Jan 1;198(1):492–504.
Deng, Wenhai, et al. “Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.J Immunol, vol. 198, no. 1, Jan. 2017, pp. 492–504. Pubmed, doi:10.4049/jimmunol.1501845.
Deng W, Yang J, Lin X, Shin J, Gao J, Zhong X-P. Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages. J Immunol. 2017 Jan 1;198(1):492–504.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

January 1, 2017

Volume

198

Issue

1

Start / End Page

492 / 504

Location

United States

Related Subject Headings

  • TOR Serine-Threonine Kinases
  • Real-Time Polymerase Chain Reaction
  • Multiprotein Complexes
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Mechanistic Target of Rapamycin Complex 1
  • Macrophages, Alveolar
  • Immunology
  • Homeostasis