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Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?

Publication ,  Conference
Yan, Z; Kim, E; Datta, D; Lewis, DA; Soderling, SH
Published in: J Neurosci
November 9, 2016

Actin polymerization governs activity-dependent modulation of excitatory synapses, including their morphology and functionality. It is clear from human genetics that neuropsychiatric and neurodevelopmental disturbances are multigenetic in nature, highlighting the need to better understand the critical neural pathways associated with these disorders and how they are altered by genetic risk alleles. One such signaling pathway that is heavily implicated by candidate genes for psychiatric and neurodevelopmental disorders are regulators of signaling to the actin cytoskeleton, suggesting that its disruption and the ensuring abnormalities of spine structures and postsynaptic complexes is a commonly affected pathway in brain disorders. This review will discuss recent experimental findings that strongly support genetic evidence linking the synaptic cytoskeleton to mental disorders, such as schizophrenia and autism spectrum disorders.

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Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

November 9, 2016

Volume

36

Issue

45

Start / End Page

11411 / 11417

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Synapses
  • Neurology & Neurosurgery
  • Mental Disorders
  • Humans
  • Dendritic Spines
  • Brain
  • Animals
  • Actins
  • Actin Cytoskeleton
 

Citation

APA
Chicago
ICMJE
MLA
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Yan, Z., Kim, E., Datta, D., Lewis, D. A., & Soderling, S. H. (2016). Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? In J Neurosci (Vol. 36, pp. 11411–11417). United States. https://doi.org/10.1523/JNEUROSCI.2360-16.2016
Yan, Zhen, Eunjoon Kim, Dibyadeep Datta, David A. Lewis, and Scott H. Soderling. “Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?” In J Neurosci, 36:11411–17, 2016. https://doi.org/10.1523/JNEUROSCI.2360-16.2016.
Yan Z, Kim E, Datta D, Lewis DA, Soderling SH. Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? In: J Neurosci. 2016. p. 11411–7.
Yan, Zhen, et al. “Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?J Neurosci, vol. 36, no. 45, 2016, pp. 11411–17. Pubmed, doi:10.1523/JNEUROSCI.2360-16.2016.
Yan Z, Kim E, Datta D, Lewis DA, Soderling SH. Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? J Neurosci. 2016. p. 11411–11417.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

November 9, 2016

Volume

36

Issue

45

Start / End Page

11411 / 11417

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Synapses
  • Neurology & Neurosurgery
  • Mental Disorders
  • Humans
  • Dendritic Spines
  • Brain
  • Animals
  • Actins
  • Actin Cytoskeleton