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cAMP response element-binding protein 1 feedback loop is necessary for consolidation of long-term synaptic facilitation in Aplysia.

Publication ,  Journal Article
Liu, R-Y; Fioravante, D; Shah, S; Byrne, JH
Published in: J Neurosci
February 20, 2008

The transcription factor cAMP response element (CRE)-binding protein (CREB) plays an essential role in the induction of many forms of long-term synaptic plasticity. Levels of CREB1, the Aplysia homolog of CREB, show sustained elevations for several hours after the induction of long-term synaptic facilitation (LTF). Furthermore, CREB1 binds to the promoter of its own gene. These results suggest the existence of a CREB1-positive feedback loop that contributes to the consolidation of LTF. In the present study, we provide a detailed, quantitative characterization of the dynamics of CREB1 mRNA and protein as well as CREB1 phosphorylation after LTF induction. Injections of CRE oligonucleotides prevented the increase in CREB1 in response to 5-HT, corroborating the existence of the CREB1 feedback loop. This loop probably sustains CRE-dependent gene transcription, which remains elevated for at least 12 h after LTF induction. LTF is blocked by injection of CREB1 antibody after the induction phase, suggesting that the CREB1-positive feedback is required for consolidation of LTF.

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Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

February 20, 2008

Volume

28

Issue

8

Start / End Page

1970 / 1976

Location

United States

Related Subject Headings

  • Synapses
  • Structural Homology, Protein
  • Neurons, Afferent
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Long-Term Potentiation
  • Feedback, Physiological
  • Cyclic AMP Response Element-Binding Protein
  • Coculture Techniques
  • Aplysia
 

Citation

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Liu, R.-Y., Fioravante, D., Shah, S., & Byrne, J. H. (2008). cAMP response element-binding protein 1 feedback loop is necessary for consolidation of long-term synaptic facilitation in Aplysia. J Neurosci, 28(8), 1970–1976. https://doi.org/10.1523/JNEUROSCI.3848-07.2008
Liu, Rong-Yu, Diasinou Fioravante, Shreyansh Shah, and John H. Byrne. “cAMP response element-binding protein 1 feedback loop is necessary for consolidation of long-term synaptic facilitation in Aplysia.J Neurosci 28, no. 8 (February 20, 2008): 1970–76. https://doi.org/10.1523/JNEUROSCI.3848-07.2008.
Liu, Rong-Yu, et al. “cAMP response element-binding protein 1 feedback loop is necessary for consolidation of long-term synaptic facilitation in Aplysia.J Neurosci, vol. 28, no. 8, Feb. 2008, pp. 1970–76. Pubmed, doi:10.1523/JNEUROSCI.3848-07.2008.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

February 20, 2008

Volume

28

Issue

8

Start / End Page

1970 / 1976

Location

United States

Related Subject Headings

  • Synapses
  • Structural Homology, Protein
  • Neurons, Afferent
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Long-Term Potentiation
  • Feedback, Physiological
  • Cyclic AMP Response Element-Binding Protein
  • Coculture Techniques
  • Aplysia