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Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise.

Publication ,  Journal Article
Jozsi, AC; Dupont-Versteegden, EE; Taylor-Jones, JM; Evans, WJ; Trappe, TA; Campbell, WW; Peterson, CA
Published in: Mech Ageing Dev
December 1, 2000

The gene expression profile of skeletal muscle from healthy older (62-75 years old) compared with younger (20-34 years old) men demonstrated elevated expression of genes typical of a stress or damage response, and decreased expression of a gene encoding a DNA repair/cell cycle checkpoint protein. Although the expression of these genes was relatively unaffected by a single bout of resistance exercise in older men, acute exercise altered gene expression in younger men such that post-exercise gene expression in younger men was similar to baseline gene expression in older men. The lack of response of muscle from older subjects to resistance exercise was also apparent in the expression of the inflammatory response gene IL-1beta, which did not differ between the age groups at baseline, but increased within 24 h of the exercise bout only in younger subjects. Other genes with potentially important roles in the adaptation of muscle to exercise, specifically in the processes of angiogenesis and cell proliferation, showed a similar response to exercise in older compared with younger subjects. Only one gene encoding the multifunctional, early growth response transcription factor EGR-1, showed an opposite pattern of expression in response to exercise, acutely decreasing in younger and increasing in older subjects. These results may provide a molecular basis for the inherent variability in the response of muscle from older as compared with younger individuals to resistance training.

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Published In

Mech Ageing Dev

DOI

ISSN

0047-6374

Publication Date

December 1, 2000

Volume

120

Issue

1-3

Start / End Page

45 / 56

Location

Ireland

Related Subject Headings

  • X-ray Repair Cross Complementing Protein 1
  • Vascular Endothelial Growth Factors
  • Vascular Endothelial Growth Factor A
  • Transcription Factors
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Muscle, Skeletal
  • Middle Aged
  • Male
  • Lymphokines
 

Citation

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Jozsi, A. C., Dupont-Versteegden, E. E., Taylor-Jones, J. M., Evans, W. J., Trappe, T. A., Campbell, W. W., & Peterson, C. A. (2000). Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise. Mech Ageing Dev, 120(1–3), 45–56. https://doi.org/10.1016/s0047-6374(00)00178-0
Jozsi, A. C., E. E. Dupont-Versteegden, J. M. Taylor-Jones, W. J. Evans, T. A. Trappe, W. W. Campbell, and C. A. Peterson. “Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise.Mech Ageing Dev 120, no. 1–3 (December 1, 2000): 45–56. https://doi.org/10.1016/s0047-6374(00)00178-0.
Jozsi AC, Dupont-Versteegden EE, Taylor-Jones JM, Evans WJ, Trappe TA, Campbell WW, et al. Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise. Mech Ageing Dev. 2000 Dec 1;120(1–3):45–56.
Jozsi, A. C., et al. “Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise.Mech Ageing Dev, vol. 120, no. 1–3, Dec. 2000, pp. 45–56. Pubmed, doi:10.1016/s0047-6374(00)00178-0.
Jozsi AC, Dupont-Versteegden EE, Taylor-Jones JM, Evans WJ, Trappe TA, Campbell WW, Peterson CA. Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise. Mech Ageing Dev. 2000 Dec 1;120(1–3):45–56.
Journal cover image

Published In

Mech Ageing Dev

DOI

ISSN

0047-6374

Publication Date

December 1, 2000

Volume

120

Issue

1-3

Start / End Page

45 / 56

Location

Ireland

Related Subject Headings

  • X-ray Repair Cross Complementing Protein 1
  • Vascular Endothelial Growth Factors
  • Vascular Endothelial Growth Factor A
  • Transcription Factors
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Muscle, Skeletal
  • Middle Aged
  • Male
  • Lymphokines