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Crosstalk Between T and B Cells in the Germinal Center After Transplantation.

Publication ,  Journal Article
Kwun, J; Manook, M; Page, E; Burghuber, C; Hong, J; Knechtle, SJ
Published in: Transplantation
April 2017

Crosstalk between B and T cells in transplantation is increasingly recognized as being important in the alloimmune response. T cell activation of B cells occurs by a 3-stage pathway, culminating with costimulation signals. We review the distinct T cell subtypes required for B-cell activation and discuss the formation of the germinal center (GC) after transplantation, with particular reference to the repopulation of the GC after depletional induction, and the subsequent effect of immunosuppressive manipulation of T cell-B cell interactions. In addition, ectopic GCs are seen in transplantation, but their role is not fully understood. Therapeutic options to target T cell-B cell interactions are of considerable interest, both as immunosuppressive tools, and to aid in the further understanding of these important alloimmune mechanisms.

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Published In

Transplantation

DOI

EISSN

1534-6080

Publication Date

April 2017

Volume

101

Issue

4

Start / End Page

704 / 712

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation Tolerance
  • T-Lymphocytes
  • Surgery
  • Organ Transplantation
  • Lymphocyte Activation
  • Kinetics
  • Immunosuppressive Agents
  • Humans
  • Graft Survival
 

Citation

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Chicago
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Kwun, J., Manook, M., Page, E., Burghuber, C., Hong, J., & Knechtle, S. J. (2017). Crosstalk Between T and B Cells in the Germinal Center After Transplantation. Transplantation, 101(4), 704–712. https://doi.org/10.1097/TP.0000000000001588
Kwun, Jean, Miriam Manook, Eugenia Page, Christopher Burghuber, Jungjoo Hong, and Stuart J. Knechtle. “Crosstalk Between T and B Cells in the Germinal Center After Transplantation.Transplantation 101, no. 4 (April 2017): 704–12. https://doi.org/10.1097/TP.0000000000001588.
Kwun J, Manook M, Page E, Burghuber C, Hong J, Knechtle SJ. Crosstalk Between T and B Cells in the Germinal Center After Transplantation. Transplantation. 2017 Apr;101(4):704–12.
Kwun, Jean, et al. “Crosstalk Between T and B Cells in the Germinal Center After Transplantation.Transplantation, vol. 101, no. 4, Apr. 2017, pp. 704–12. Pubmed, doi:10.1097/TP.0000000000001588.
Kwun J, Manook M, Page E, Burghuber C, Hong J, Knechtle SJ. Crosstalk Between T and B Cells in the Germinal Center After Transplantation. Transplantation. 2017 Apr;101(4):704–712.

Published In

Transplantation

DOI

EISSN

1534-6080

Publication Date

April 2017

Volume

101

Issue

4

Start / End Page

704 / 712

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation Tolerance
  • T-Lymphocytes
  • Surgery
  • Organ Transplantation
  • Lymphocyte Activation
  • Kinetics
  • Immunosuppressive Agents
  • Humans
  • Graft Survival