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Developmental neurotoxicity of succeeding generations of insecticides.

Publication ,  Journal Article
Abreu-Villaça, Y; Levin, ED
Published in: Environ Int
February 2017

Insecticides are by design toxic. They must be toxic to effectively kill target species of insects. Unfortunately, they also have off-target toxic effects that can harm other species, including humans. Developmental neurotoxicity is one of the most prominent off-target toxic risks of insecticides. Over the past seven decades several classes of insecticides have been developed, each with their own mechanisms of effect and toxic side effects. This review covers the developmental neurotoxicity of the succeeding generations of insecticides including organochlorines, organophosphates, pyrethroids, carbamates and neonicotinoids. The goal of new insecticide development is to more effectively kill target species with fewer toxic side effects on non-target species. From the experience with the developmental neurotoxicity caused by the generations of insecticides developed in the past advice is offered how to proceed with future insecticide development to decrease neurotoxic risk.

Duke Scholars

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Published In

Environ Int

DOI

EISSN

1873-6750

Publication Date

February 2017

Volume

99

Start / End Page

55 / 77

Location

Netherlands

Related Subject Headings

  • Pyrethrins
  • Organophosphates
  • Neurotoxins
  • Nervous System
  • Insecticides
  • Humans
  • Environmental Sciences
  • Animals
 

Citation

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Abreu-Villaça, Y., & Levin, E. D. (2017). Developmental neurotoxicity of succeeding generations of insecticides. Environ Int, 99, 55–77. https://doi.org/10.1016/j.envint.2016.11.019
Abreu-Villaça, Yael, and Edward D. Levin. “Developmental neurotoxicity of succeeding generations of insecticides.Environ Int 99 (February 2017): 55–77. https://doi.org/10.1016/j.envint.2016.11.019.
Abreu-Villaça Y, Levin ED. Developmental neurotoxicity of succeeding generations of insecticides. Environ Int. 2017 Feb;99:55–77.
Abreu-Villaça, Yael, and Edward D. Levin. “Developmental neurotoxicity of succeeding generations of insecticides.Environ Int, vol. 99, Feb. 2017, pp. 55–77. Pubmed, doi:10.1016/j.envint.2016.11.019.
Abreu-Villaça Y, Levin ED. Developmental neurotoxicity of succeeding generations of insecticides. Environ Int. 2017 Feb;99:55–77.
Journal cover image

Published In

Environ Int

DOI

EISSN

1873-6750

Publication Date

February 2017

Volume

99

Start / End Page

55 / 77

Location

Netherlands

Related Subject Headings

  • Pyrethrins
  • Organophosphates
  • Neurotoxins
  • Nervous System
  • Insecticides
  • Humans
  • Environmental Sciences
  • Animals