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Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques.

Publication ,  Journal Article
Pahar, B; Kenway-Lynch, CS; Marx, P; Srivastav, SK; LaBranche, C; Montefiori, DC; Das, A
Published in: Virol J
December 1, 2016

BACKGROUND: Increasing evidence suggests an unexpected potential for non-neutralizing antibodies to prevent HIV infection. Consequently, identification of functional linear B-cell epitopes for HIV are important for developing preventative and therapeutic strategies. We therefore explored the role of antigen-specific immune responses in controlling plasma viremia in SIV infected rhesus macaques. METHODS: Thirteen rhesus macaques were inoculated either intravaginally or intrarectally with SIVMAC251. Peripheral blood CD4+ T-cells were quantified. Plasma was examined for viremia, antigen specific IgG, IgA and IgM binding responses and neutralizing antibodies. Regions containing binding epitopes for antigen-specific IgG, IgM and IgA responses were determined, and the minimum size of linear Envelope epitope responsible for binding antibodies was identified. RESULTS: The presence of neutralizing antibodies did not correlate the outcome of the disease. In a few SIV-infected macaques, antigen-specific IgG and IgM responses in plasma correlated with decreased plasma viremia. Early induction and the breadth of antigen-specific IgG responses were found to be significantly correlated with the control of plasma viral load. Immunoglobulin classes share similar functional linear B-cell epitopes. SIV-specific linear envelope B-cell epitopes were found to be 12 amino-acids in length. CONCLUSIONS: Early induction of combination of peptide-specific IgG responses were found to be responsible for the control of plasma viral load and indicative of disease outcome in SIV-infected rhesus macaques and might be important for the development of therapeutic strategies for control or prevention of HIV/AIDS.

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Published In

Virol J

DOI

EISSN

1743-422X

Publication Date

December 1, 2016

Volume

13

Issue

1

Start / End Page

200

Location

England

Related Subject Headings

  • Virology
  • Viremia
  • Viral Load
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Male
  • Macaca mulatta
  • Immunoglobulin M
  • Immunoglobulin G
 

Citation

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Pahar, B., Kenway-Lynch, C. S., Marx, P., Srivastav, S. K., LaBranche, C., Montefiori, D. C., & Das, A. (2016). Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques. Virol J, 13(1), 200. https://doi.org/10.1186/s12985-016-0652-x
Pahar, Bapi, Carys S. Kenway-Lynch, Preston Marx, Sudesh K. Srivastav, Celia LaBranche, David C. Montefiori, and Arpita Das. “Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques.Virol J 13, no. 1 (December 1, 2016): 200. https://doi.org/10.1186/s12985-016-0652-x.
Pahar B, Kenway-Lynch CS, Marx P, Srivastav SK, LaBranche C, Montefiori DC, et al. Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques. Virol J. 2016 Dec 1;13(1):200.
Pahar, Bapi, et al. “Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques.Virol J, vol. 13, no. 1, Dec. 2016, p. 200. Pubmed, doi:10.1186/s12985-016-0652-x.
Pahar B, Kenway-Lynch CS, Marx P, Srivastav SK, LaBranche C, Montefiori DC, Das A. Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques. Virol J. 2016 Dec 1;13(1):200.
Journal cover image

Published In

Virol J

DOI

EISSN

1743-422X

Publication Date

December 1, 2016

Volume

13

Issue

1

Start / End Page

200

Location

England

Related Subject Headings

  • Virology
  • Viremia
  • Viral Load
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Male
  • Macaca mulatta
  • Immunoglobulin M
  • Immunoglobulin G