Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong In Vitro Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds.
Publication
, Journal Article
Schell, WA; Jones, AM; Garvey, EP; Hoekstra, WJ; Schotzinger, RJ; Alexander, BD
Published in: Antimicrob Agents Chemother
March 2017
The in vitro activities of fungal CYP51 inhibitors VT-1161 and VT-1129 were determined for Candida glabrata (n = 34) and C. krusei (n = 50). C. glabrata isolates were screened for FKS gene mutations. All isolates were resistant clinically and/or in vitro to at least one standard antifungal compound. VT-1161 and VT-1129 MICs for all isolates were at least 5-fold below achievable human plasma levels for VT-1161. VT-1161 and VT-1129 are promising for the treatment of resistant C. glabrata and C. krusei infections.
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Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
March 2017
Volume
61
Issue
3
Location
United States
Related Subject Headings
- Tetrazoles
- Pyridines
- Mutation
- Microbiology
- Microbial Sensitivity Tests
- Humans
- Glucosyltransferases
- Gene Expression
- Fungal Proteins
- Echinocandins
Citation
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MLA
NLM
Schell, W. A., Jones, A. M., Garvey, E. P., Hoekstra, W. J., Schotzinger, R. J., & Alexander, B. D. (2017). Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong In Vitro Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds. Antimicrob Agents Chemother, 61(3). https://doi.org/10.1128/AAC.01817-16
Schell, W. A., A. M. Jones, E. P. Garvey, W. J. Hoekstra, R. J. Schotzinger, and B. D. Alexander. “Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong In Vitro Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds.” Antimicrob Agents Chemother 61, no. 3 (March 2017). https://doi.org/10.1128/AAC.01817-16.
Schell WA, Jones AM, Garvey EP, Hoekstra WJ, Schotzinger RJ, Alexander BD. Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong In Vitro Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds. Antimicrob Agents Chemother. 2017 Mar;61(3).
Schell, W. A., et al. “Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong In Vitro Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds.” Antimicrob Agents Chemother, vol. 61, no. 3, Mar. 2017. Pubmed, doi:10.1128/AAC.01817-16.
Schell WA, Jones AM, Garvey EP, Hoekstra WJ, Schotzinger RJ, Alexander BD. Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong In Vitro Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds. Antimicrob Agents Chemother. 2017 Mar;61(3).
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
March 2017
Volume
61
Issue
3
Location
United States
Related Subject Headings
- Tetrazoles
- Pyridines
- Mutation
- Microbiology
- Microbial Sensitivity Tests
- Humans
- Glucosyltransferases
- Gene Expression
- Fungal Proteins
- Echinocandins