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Transmission of Multiple HIV-1 Subtype C Transmitted/founder Viruses into the Same Recipients Was not Determined by Modest Phenotypic Differences.

Publication ,  Journal Article
Song, H; Hora, B; Giorgi, EE; Kumar, A; Cai, F; Bhattacharya, T; Perelson, AS; Gao, F
Published in: Sci Rep
December 2, 2016

A severe bottleneck exists during HIV-1 mucosal transmission. However, viral properties that determine HIV-1 transmissibility are not fully elucidated. We identified multiple transmitted/founder (T/F) viruses in six HIV-1-infected subjects by analyzing whole genome sequences. Comparison of biological phenotypes of different T/F viruses from the same individual allowed us to more precisely identify critical determinants for viral transmissibility since they were transmitted under similar conditions. All T/F viruses used coreceptor CCR5, while no T/F viruses used CXCR4 or GPR15. However, the efficiency for different T/F viruses from the same individual to use CCR5 was significantly variable, and the differences were even more significant for usage of coreceptors FPRL1, CCR3 and APJ. Resistance to IFN-α was also different between T/F viruses in 2 of 3 individuals. The relative fitness between T/F viruses from the same subject was highly variable (2-6%). Importantly, the levels of coreceptor usage efficiency, resistance to IFN-α and viral fitness were not associated with proportions of T/F viruses in each individual during acute infection. Our results show that the modest but significant differences in coreceptor usage efficiency, IFN-α sensitivity and viral fitness each alone may not play a critical role in HIV-1 transmission.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

December 2, 2016

Volume

6

Start / End Page

38130

Location

England

Related Subject Headings

  • Virus Replication
  • Viral Tropism
  • Receptors, HIV
  • Receptors, CCR5
  • Phenotype
  • Male
  • Interferon-alpha
  • Humans
  • HIV-1
  • HIV Infections
 

Citation

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MLA
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Song, H., Hora, B., Giorgi, E. E., Kumar, A., Cai, F., Bhattacharya, T., … Gao, F. (2016). Transmission of Multiple HIV-1 Subtype C Transmitted/founder Viruses into the Same Recipients Was not Determined by Modest Phenotypic Differences. Sci Rep, 6, 38130. https://doi.org/10.1038/srep38130
Song, Hongshuo, Bhavna Hora, Elena E. Giorgi, Amit Kumar, Fangping Cai, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. “Transmission of Multiple HIV-1 Subtype C Transmitted/founder Viruses into the Same Recipients Was not Determined by Modest Phenotypic Differences.Sci Rep 6 (December 2, 2016): 38130. https://doi.org/10.1038/srep38130.
Song, Hongshuo, et al. “Transmission of Multiple HIV-1 Subtype C Transmitted/founder Viruses into the Same Recipients Was not Determined by Modest Phenotypic Differences.Sci Rep, vol. 6, Dec. 2016, p. 38130. Pubmed, doi:10.1038/srep38130.
Song H, Hora B, Giorgi EE, Kumar A, Cai F, Bhattacharya T, Perelson AS, Gao F. Transmission of Multiple HIV-1 Subtype C Transmitted/founder Viruses into the Same Recipients Was not Determined by Modest Phenotypic Differences. Sci Rep. 2016 Dec 2;6:38130.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

December 2, 2016

Volume

6

Start / End Page

38130

Location

England

Related Subject Headings

  • Virus Replication
  • Viral Tropism
  • Receptors, HIV
  • Receptors, CCR5
  • Phenotype
  • Male
  • Interferon-alpha
  • Humans
  • HIV-1
  • HIV Infections