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Analysis of in vitro chemoresponse assays in endometrioid endometrial adenocarcinoma: an observational ancillary analysis.

Publication ,  Journal Article
Davidson, BA; Foote, J; Brower, SL; Tian, C; Havrilesky, LJ; Secord, AA
Published in: Gynecol Oncol Res Pract
2016

BACKGROUND: Chemotherapy plays a role in the treatment of endometrioid endometrial cancer (EEC); however, tumor grade may affect response. Our objective was to evaluate associations between tumor grade and in vitro chemoresponse. METHODS: We conducted an analysis of primary tumor samples from women with EEC undergoing in vitro chemoresponse testing. Results were classified as sensitive (S), intermediate (I), or resistant (R) to each drug tested. Correlations between tumor grade and response were examined. RESULTS: Data was collected from 159 patients: 28 with grade 1 (18%), 52 with grade 2 (32%), and 79 (50%) with grade 3 tumors. Median age of patients was 62 (range 31-92). Most patients were Caucasian (83%) with advanced disease (Stage III: 50.9%; Stage IV: 13.2%). Overall chemoresponse was similar across all grades. Fifty percent, 56 and 51% for grade 1, 2, and 3 tumors, respectively, demonstrated S results to at least 1 agent. There was no association between grade and in vitro response to chemotherapy agents (p > 0.05) except a marginal association between grade and doxorubicin response (p = 0.08). Grade 1 and 2 cancers were more likely to demonstrate R results for doxorubicin compared to grade 3 cancers (G1: 19% vs G2: 25% vs G3: 8%; p = 0.08). In a subset tested for all 7 agents, only one patient tumor was pan-R and 4 were pan-S. CONCLUSIONS: Based on our data, grades 1-3 EEC have similar in vitro chemoresponse. These findings suggest that chemotherapy may be useful in advanced low grade EECs, but further clinical correlation is needed.

Duke Scholars

Published In

Gynecol Oncol Res Pract

DOI

ISSN

2053-6844

Publication Date

2016

Volume

3

Start / End Page

13

Location

England

Related Subject Headings

  • 3215 Reproductive medicine
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1114 Paediatrics and Reproductive Medicine
  • 1112 Oncology and Carcinogenesis
 

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Davidson, B. A., Foote, J., Brower, S. L., Tian, C., Havrilesky, L. J., & Secord, A. A. (2016). Analysis of in vitro chemoresponse assays in endometrioid endometrial adenocarcinoma: an observational ancillary analysis. Gynecol Oncol Res Pract, 3, 13. https://doi.org/10.1186/s40661-016-0032-7
Davidson, Brittany A., Jonathan Foote, Stacey L. Brower, Chunqiao Tian, Laura J. Havrilesky, and Angeles Alvarez Secord. “Analysis of in vitro chemoresponse assays in endometrioid endometrial adenocarcinoma: an observational ancillary analysis.Gynecol Oncol Res Pract 3 (2016): 13. https://doi.org/10.1186/s40661-016-0032-7.
Davidson BA, Foote J, Brower SL, Tian C, Havrilesky LJ, Secord AA. Analysis of in vitro chemoresponse assays in endometrioid endometrial adenocarcinoma: an observational ancillary analysis. Gynecol Oncol Res Pract. 2016;3:13.
Davidson, Brittany A., et al. “Analysis of in vitro chemoresponse assays in endometrioid endometrial adenocarcinoma: an observational ancillary analysis.Gynecol Oncol Res Pract, vol. 3, 2016, p. 13. Pubmed, doi:10.1186/s40661-016-0032-7.
Davidson BA, Foote J, Brower SL, Tian C, Havrilesky LJ, Secord AA. Analysis of in vitro chemoresponse assays in endometrioid endometrial adenocarcinoma: an observational ancillary analysis. Gynecol Oncol Res Pract. 2016;3:13.
Journal cover image

Published In

Gynecol Oncol Res Pract

DOI

ISSN

2053-6844

Publication Date

2016

Volume

3

Start / End Page

13

Location

England

Related Subject Headings

  • 3215 Reproductive medicine
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1114 Paediatrics and Reproductive Medicine
  • 1112 Oncology and Carcinogenesis