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WE-C-116-07: Tumor Enhancement Using Deformable Image Registration for Four-Dimensional Magnetic Resonance Imaging (4D-MRI): A Feasibility Study.

Publication ,  Journal Article
Yang, J; Cai, J; Wang, H; Chang, Z; Czito, B; Bashir, M; Yin, F
Published in: Med Phys
June 2013

PURPOSE: We have previously developed a 4D-MRI technique using the fast imaging sequence employing steady-state acquisition (FIESTA) sequence, which has suboptimal tumor-to-tissue contrast-to-noise ratio (CNR) due to its T2*/T1 weighting. This study investigated the feasibility of enhancing the tumor-to-tissue CNR using deformable image registration (DIR). METHODS: Five patients with cancers in the liver were included in an IRB-approved study. 4D-MRI images were acquired on a 1.5T GE scanner and reconstructed off line using in-house developed program. All patients were also imaged with a T2-w fast recovery fast spin-echo (FRFSE) sequence at the end-of-exhalation phase. Deformation vectors between respiratory phases of the 4D-MRI were determined using commercial software. Pseudo 'enhanced' 4D-MRI was then generated by applying the deformation vectors to the T2-w FRFSE MR images. Motion trajectories of tumor and diaphragm and tumor-to-tissue CNR were compared between the original T2*/T1-w 4D-MRI and the 'enhanced' T2-w 4D-MRI. To validate our method, we performed a simulation study based on a 4D digital human phantom. MR images with T2*/T1-w and T2-w with were generated by assigning organ intensities corresponding to those in FIESTA and FRFSE images, respectively. RESULTS: In the phantom study, motion trajectories of the hypothesized 'tumor' matched excellently between the original T2*/T1-w 4D-MRI and the 'enhanced' T2-w 4D-MRI. Mean(±SD) absolute difference in motion amplitude was 0.66 (±0.62) mm. In the patient study, tumor and diaphragm motion trajectories closely matched between the two 4D-MRIs: mean correlation coefficient was great than 0.97 in all directions; the mean (±SD) absolute difference in motion amplitude was smaller than 0.55(±0.19) mm. Tumor-to-tissue CNR was significantly improved from 7.57(±5.6) in the original 4D-MRI to 23.75(±15.8) in the 'enhanced' 4D-MRI. CONCLUSION: It is feasible to improve tumor-to-tissue CNR of T2*/T1-w 4D-MRI using the DIR method. The 'enhanced' 4D-MRI retained comparable tumor motion information as the original 4D-MRI. This work is partly supported by funding from NIH (1R21CA165384-01A1) and a research grant from the Golfers Against Cancer (GAC) Foundation.

Duke Scholars

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2013

Volume

40

Issue

6Part29

Start / End Page

485

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yang, J., Cai, J., Wang, H., Chang, Z., Czito, B., Bashir, M., & Yin, F. (2013). WE-C-116-07: Tumor Enhancement Using Deformable Image Registration for Four-Dimensional Magnetic Resonance Imaging (4D-MRI): A Feasibility Study. Med Phys, 40(6Part29), 485. https://doi.org/10.1118/1.4815569
Yang, J., J. Cai, H. Wang, Z. Chang, B. Czito, M. Bashir, and F. Yin. “WE-C-116-07: Tumor Enhancement Using Deformable Image Registration for Four-Dimensional Magnetic Resonance Imaging (4D-MRI): A Feasibility Study.Med Phys 40, no. 6Part29 (June 2013): 485. https://doi.org/10.1118/1.4815569.
Yang, J., et al. “WE-C-116-07: Tumor Enhancement Using Deformable Image Registration for Four-Dimensional Magnetic Resonance Imaging (4D-MRI): A Feasibility Study.Med Phys, vol. 40, no. 6Part29, June 2013, p. 485. Pubmed, doi:10.1118/1.4815569.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2013

Volume

40

Issue

6Part29

Start / End Page

485

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences