On the assessment of variability in bioavailability/bioequivalence studies
Publication
, Journal Article
Liu, JP; Chow, SC
Published in: Communications in Statistics - Theory and Methods
January 1, 1992
A procedure is proposed for the assessment of bioequivalence of variabilities between two formulations in bioavailability/bioequivalence studies. This procedure is essentially a two one-sided Pitman-Morgan's tests procedure which is based on the correlation between crossover differences and subject totals. The nonparametric version of the proposed test is also discussed. A dataset of AUC from a 2x2 crossover bioequivalence trial is presented to illustrate the proposed procedures. © 1992, Taylor & Francis Group, LLC. All rights reserved.
Duke Scholars
Published In
Communications in Statistics - Theory and Methods
DOI
EISSN
1532-415X
ISSN
0361-0926
Publication Date
January 1, 1992
Volume
21
Issue
9
Start / End Page
2591 / 2607
Related Subject Headings
- Statistics & Probability
- 0199 Other Mathematical Sciences
- 0104 Statistics
Citation
APA
Chicago
ICMJE
MLA
NLM
Liu, J. P., & Chow, S. C. (1992). On the assessment of variability in bioavailability/bioequivalence studies. Communications in Statistics - Theory and Methods, 21(9), 2591–2607. https://doi.org/10.1080/03610929208830932
Liu, J. P., and S. C. Chow. “On the assessment of variability in bioavailability/bioequivalence studies.” Communications in Statistics - Theory and Methods 21, no. 9 (January 1, 1992): 2591–2607. https://doi.org/10.1080/03610929208830932.
Liu JP, Chow SC. On the assessment of variability in bioavailability/bioequivalence studies. Communications in Statistics - Theory and Methods. 1992 Jan 1;21(9):2591–607.
Liu, J. P., and S. C. Chow. “On the assessment of variability in bioavailability/bioequivalence studies.” Communications in Statistics - Theory and Methods, vol. 21, no. 9, Jan. 1992, pp. 2591–607. Scopus, doi:10.1080/03610929208830932.
Liu JP, Chow SC. On the assessment of variability in bioavailability/bioequivalence studies. Communications in Statistics - Theory and Methods. 1992 Jan 1;21(9):2591–2607.
Published In
Communications in Statistics - Theory and Methods
DOI
EISSN
1532-415X
ISSN
0361-0926
Publication Date
January 1, 1992
Volume
21
Issue
9
Start / End Page
2591 / 2607
Related Subject Headings
- Statistics & Probability
- 0199 Other Mathematical Sciences
- 0104 Statistics