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Radiation therapy following radical prostatectomy

Publication ,  Journal Article
Lee, WR; Hanks, GE
Published in: Cancer
January 1, 1995

Background. The incidence of pathologic upstaging to stage T3 is a common occurrence in patients undergoing radical prostatectomy for clinical stage T1‐2 prostate cancer. There is a considerable risk of local recurrence owing radical prostatectomy for pathologic stage T3 cancers. Postoperative adjuvant radiation therapy has been used to reduce the incidence of local recurrence. Methods. The available data in series using radiation therapy following radical prostatectomy are reviewed. Results. The available data demonstrate that adjuvant pelvic radiation therapy reduces the risk of clinical local failure from 30‐60% to 0‐10% in patients with high risk pathologic features following radical prostatectomy, Most patients who receive radiation therapy to the pelvis for a persistently elevated serum prostate specific antigen (PSA) level following radical prostatectomy will have a subsequent decrease in the serum PSA level. The incidence of severe complications related to postprostatectomy radiation therapy is 5‐10%, and there is no evidence that the risk of incontinence or urethral stricture is increased with the addition of radiation therapy. Conclusions. Radiation therapy following radical prostatectomy can reduce the rate of clinical local failure in patients with high risk features following radical prostatectomy. Radiation therapy can be administered following radical prostatectomy with acceptable treatment‐related morbidity. There is no evidence that postprostatectomy radiation therapy improves disease free survival. Cancer 1995;75:1909–13. Copyright © 1995 American Cancer Society

Duke Scholars

Published In

Cancer

DOI

EISSN

1097-0142

ISSN

0008-543X

Publication Date

January 1, 1995

Volume

75

Issue

7 S

Start / End Page

1909 / 1913

Related Subject Headings

  • Oncology & Carcinogenesis
  • 4206 Public health
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis
 

Citation

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MLA
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Lee, W. R., & Hanks, G. E. (1995). Radiation therapy following radical prostatectomy. Cancer, 75(7 S), 1909–1913. https://doi.org/10.1002/1097-0142(19950401)75:7+<1909::AID-CNCR2820751625>3.0.CO;2-F
Lee, W. R., and G. E. Hanks. “Radiation therapy following radical prostatectomy.” Cancer 75, no. 7 S (January 1, 1995): 1909–13. https://doi.org/10.1002/1097-0142(19950401)75:7+<1909::AID-CNCR2820751625>3.0.CO;2-F.
Lee WR, Hanks GE. Radiation therapy following radical prostatectomy. Cancer. 1995 Jan 1;75(7 S):1909–13.
Lee, W. R., and G. E. Hanks. “Radiation therapy following radical prostatectomy.” Cancer, vol. 75, no. 7 S, Jan. 1995, pp. 1909–13. Scopus, doi:10.1002/1097-0142(19950401)75:7+<1909::AID-CNCR2820751625>3.0.CO;2-F.
Lee WR, Hanks GE. Radiation therapy following radical prostatectomy. Cancer. 1995 Jan 1;75(7 S):1909–1913.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

ISSN

0008-543X

Publication Date

January 1, 1995

Volume

75

Issue

7 S

Start / End Page

1909 / 1913

Related Subject Headings

  • Oncology & Carcinogenesis
  • 4206 Public health
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis