Early effects of feeding lysine and threonine deficient and supplemented rice diets on distribution and synthesis of molecular species of phosphatidyl choline in weanling rat liver
Effect of feeding lysine and threonine deficient and supplemented rice diets to weanling rats for one day has been studied on the relative distribution and synthesis of molecular species of phosphatidyl choline from choline 1,2- 14C and methionine methyl 14C in liver. Liver total phospholipids and phosphatidyl choline and the incorporation of choline 1,2-14C and methionine 14C in the two groups were not significantly different. A significant reduction both in the amounts and in the incorporation of choline 1,2 14C into monoenoic + dienoic species of phosphatidyl choline was observed in deficient rats as compared to supplemented rats. The amounts of fed tetraenoic and hexaenoic species of phosphatidyl choline and their synthesis from methionine 14C were not significantly different in the two groups. The incorporation of choline 1,2 14C into tetraenoic species of phosphatidyl choline was significantly reduced in deficient rats as compared to the supplemented rats. The results showed that feeding of lysine and reduced both the amounts and synthesis of the molecular species of phosphatidyl choline synthesized by CDP choline pathway.
