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Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash.

Publication ,  Journal Article
Srivastava, PK; Chauhan, SS; Misra, UK
Published in: Arch Toxicol
February 1986

The effects of intratracheal administration of fly ash (50 mg/kg body weight, daily for 7 days) on hepatic microsomal phospholipid metabolism has been studied in rats using various phospholipid precursors, viz NaH2(32)PO4, (methyl-14C)-choline, and (methyl-14C)-methionine. Fly ash administration significantly increased microsomal phosphatidylcholine (PC), and lysophosphatidylcholine (LPC). The incorporation of NaH2(32)PO4 into total liver phospholipids, PC and Phosphatidyl ethanolamine (PE) was significantly increased in fly ash-treated rats as compared to the control. Fly ash administration also increased the incorporation of (methyl-14C)-choline into microsomal PC. Incorporation of (methyl-14C)-methionine into microsomal PC was not affected. Fly ash administration decreased the per cent distribution of arachidonic acid in PC and PE and increased that of oleic acid in PC and of linoleic acid in PE.

Duke Scholars

Published In

Arch Toxicol

DOI

ISSN

0340-5761

Publication Date

February 1986

Volume

58

Issue

3

Start / End Page

199 / 202

Location

Germany

Related Subject Headings

  • Trachea
  • Toxicology
  • Rats, Inbred Strains
  • Rats
  • Phospholipids
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Phosphates
  • Particulate Matter
  • Microsomes, Liver
 

Citation

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Srivastava, P. K., Chauhan, S. S., & Misra, U. K. (1986). Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash. Arch Toxicol, 58(3), 199–202. https://doi.org/10.1007/BF00340982
Srivastava, P. K., S. S. Chauhan, and U. K. Misra. “Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash.Arch Toxicol 58, no. 3 (February 1986): 199–202. https://doi.org/10.1007/BF00340982.
Srivastava PK, Chauhan SS, Misra UK. Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash. Arch Toxicol. 1986 Feb;58(3):199–202.
Srivastava, P. K., et al. “Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash.Arch Toxicol, vol. 58, no. 3, Feb. 1986, pp. 199–202. Pubmed, doi:10.1007/BF00340982.
Srivastava PK, Chauhan SS, Misra UK. Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash. Arch Toxicol. 1986 Feb;58(3):199–202.
Journal cover image

Published In

Arch Toxicol

DOI

ISSN

0340-5761

Publication Date

February 1986

Volume

58

Issue

3

Start / End Page

199 / 202

Location

Germany

Related Subject Headings

  • Trachea
  • Toxicology
  • Rats, Inbred Strains
  • Rats
  • Phospholipids
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Phosphates
  • Particulate Matter
  • Microsomes, Liver