Second messenger and its regulatory enzymes under protein nutrition

In rat pancreatic tissue the levels of cAMP are elevated in protein deficient diet and lowered in the case of protein rich diet. The activity of the enzymes for the synthesis and degradation of this molecule namely adenylate cyclase (AC) and phosphodiesterase (PDE) is markedly lowered in the case of deficient diet feeding and elevated in the case of protein rich diet feeding. However, both the enzymes are influenced to a different magnitude under the different dietary conditions and the levels of cAMP seems to be governed by the net balance of these anabolic and catabolic activities. Thus dietary status of animals seems to exert significant control on the level of cAMP in pancreas. © 1989 Pergamon Press plc.

Duke Scholars

Author Uma Kant Misra Pathology