Skip to main content
Journal cover image

Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation.

Publication ,  Journal Article
Chauhan, SS; Misra, UK
Published in: Biochem Pharmacol
January 15, 1991

Fly ash contains many polycyclic aromatic hydrocarbons and genotoxic trace elements. In rats, fly ash exposure profoundly affects lung and liver histology. In the present study, the effect of fly ash inhalation on lung and liver lipids of rats was examined. Male Wistar strain rats were exposed daily to fly ash (0.27 +/- 0.01 mg/L air) in an inhalation chamber, 6 hr daily over a period of 15 days, and were killed on various days, i.e. 16, 30, 60, and 120. Fly ash inhalation significantly (P less than 0.05) increased total phospholipids (PL), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) in lungs. PC and dipalmitoylphosphatidylcholine (DPPC) contents in microsomes and lung surfactant also were significantly (P less than 0.05) higher in rats exposed to fly ash compared to control group animals. Radiolabeled precursor incorporation studies indicated that fly ash induced the synthesis of PC and DPPC by both CDP-choline pathway and N-methylation of PE in lung microsomes and enhanced their secretion into lung surfactant. In liver, PC and PE contents were elevated significantly (P less than 0.05) by fly ash exposure on days 16 and 30 respectively. A similar elevation of PC was observed in hepatic microsomes; this increase was due to its increased synthesis. However, the increased synthesis of PC in liver occurred to a greater extent by the N-methylation pathway than by the CDP-choline pathway.

Duke Scholars

Published In

Biochem Pharmacol

DOI

ISSN

0006-2952

Publication Date

January 15, 1991

Volume

41

Issue

2

Start / End Page

191 / 198

Location

England

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Pulmonary Surfactants
  • Phospholipids
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Pharmacology & Pharmacy
  • Particulate Matter
  • Male
  • Lung
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chauhan, S. S., & Misra, U. K. (1991). Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation. Biochem Pharmacol, 41(2), 191–198. https://doi.org/10.1016/0006-2952(91)90476-l
Chauhan, S. S., and U. K. Misra. “Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation.Biochem Pharmacol 41, no. 2 (January 15, 1991): 191–98. https://doi.org/10.1016/0006-2952(91)90476-l.
Chauhan SS, Misra UK. Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation. Biochem Pharmacol. 1991 Jan 15;41(2):191–8.
Chauhan, S. S., and U. K. Misra. “Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation.Biochem Pharmacol, vol. 41, no. 2, Jan. 1991, pp. 191–98. Pubmed, doi:10.1016/0006-2952(91)90476-l.
Chauhan SS, Misra UK. Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation. Biochem Pharmacol. 1991 Jan 15;41(2):191–198.
Journal cover image

Published In

Biochem Pharmacol

DOI

ISSN

0006-2952

Publication Date

January 15, 1991

Volume

41

Issue

2

Start / End Page

191 / 198

Location

England

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Pulmonary Surfactants
  • Phospholipids
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Pharmacology & Pharmacy
  • Particulate Matter
  • Male
  • Lung