Rice diet deficient in lysine and threonine alters normal cholesterol metabolism of rat hepatic Golgi apparatus

The effects of feeding a diet deficient in lysine and threonine on the cholesterol metabolism of rat hepatic Golgi apparatus and microsomes was studied. Rice diet without supplementation of lysine and threonine resulted in decreased cholesterol contents of whole liver and hepatic Golgi as compared to the casein diet, but it did not affect the microsomal cholesterol content. Sodium 3H-acetate incorporation studies showed that Golgi cholesterol synthesis and its turnover was significantly reduced in rats fed a deficient diet as compared with those fed a casein diet. However, feeding of lysine and threonine additionally to the rats of deficient group could improve the altered cholesterol metabolism in rat hepatic Golgi apparatus. © 1987 Pergamon Journals Ltd. All rights reserved.

Duke Scholars

Author Uma Kant Misra Pathology